Mitigation of Fibrosis after Myocardial Infarction in Rats by Using a Porcine Cholecyst Extracellular Matrix

Fibrosis that occurs after nonfatal myocardial infarction (MI) is an irreversible reparative cardiac tissue remodeling process characterized by progressive deposition of highly cross-linked type I collagen. No currently available therapeutic strategy prevents or reverses MI-associated fibrotic scarr...

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Bibliographic Details
Published in:Comparative medicine 2023-08, Vol.73 (4), p.312-322
Main Authors: Nair, Reshma S, Sobhan, Praveen K, Shenoy, Sachin J, Prabhu, Mukund A, Kumar, Vikas, Ramachandran, Surya, Anilkumar, Thapasimuthu V
Format: Article
Language:English
Subjects:
Animals
Cicatrix - pathology
Collagen Type I
Extracellular Matrix - pathology
Fibrosis
Myocardial Infarction - complications
Myocardial Infarction - pathology
Myocardium - pathology
Original Research
Rats
Swine
Swine Diseases
Ventricular Remodeling
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Summary:Fibrosis that occurs after nonfatal myocardial infarction (MI) is an irreversible reparative cardiac tissue remodeling process characterized by progressive deposition of highly cross-linked type I collagen. No currently available therapeutic strategy prevents or reverses MI-associated fibrotic scarring of myocardium. In this study, we used an epicardial graft prepared of porcine cholecystic extracellular matrix to treat experimental nonfatal MI in rats. Graft-assisted healing was characterized by reduced fibrosis, with scanty deposition of type I collagen. Histologically, the tissue response was associated with a favorable regenerative reaction predominated by CD4-positive helper T lymphocytes, enhanced angiogenesis, and infiltration of proliferating cells. These observations indicate that porcine cholecystic extracellular matrix delayed the fibrotic reactionand support its use as a potential biomaterial for mitigating fibrosis after MI. Delaying the progression of cardiac tissueremodeling may widen the therapeutic window for management of scarring after MI.
ISSN:1532-0820
2769-819X
DOI:10.30802/AALAS-CM-22-000097