Relationships between cytokines and cognitive function from pre- to post-chemotherapy in patients with breast cancer

Cancer-related cognitive decline (CRCD) is a clinically important problem and negatively affects daily functioning and quality of life. We conducted a pilot longitudinal study from pre- to post-chemotherapy in patients with breast cancer to assess changes in inflammation and cognition over time, as...

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Published in:Journal of neuroimmunology 2022-01, Vol.362, p.577769-577769, Article 577769
Main Authors: Janelsins, Michelle C., Lei, Lianlian, Netherby-Winslow, Colleen, Kleckner, Amber S., Kerns, Sarah, Gilmore, Nikesha, Belcher, Elizabeth, Thompson, Bryan D., Werner, Zachary A., Hopkins, Judith O., Long, Joan, Cole, Sharon, Culakova, Eva
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - adverse effects
Breast Neoplasms - drug therapy
cancer
Cancer-related cognitive decline (CRCD)
Chemotherapy
Cognition
Cognitive Dysfunction - chemically induced
Cognitive Dysfunction - immunology
Cohort Studies
Cytokines
Cytokines - blood
Cytokines - immunology
Female
Humans
Inflammation - chemically induced
Inflammation - immunology
Longitudinal Studies
Middle Aged
Pilot Projects
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Summary:Cancer-related cognitive decline (CRCD) is a clinically important problem and negatively affects daily functioning and quality of life. We conducted a pilot longitudinal study from pre- to post-chemotherapy in patients with breast cancer to assess changes in inflammation and cognition over time, as well as the impact of baseline cytokine level on post-chemotherapy cognitive scores. We found that concentrations of IL-6, MCP-1, sTNFRI, and sTNFRII significantly increased in patients, while IL-1β significantly decreased (p 
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2021.577769