Hypothalamic Supramammillary Control of Cognition and Motivation

The supramammillary nucleus (SuM) is a small region in the ventromedial posterior hypothalamus. The SuM has been relatively understudied with much of the prior focus being on its connection with septo-hippocampal circuitry. Thus, most studies conducted until the 21st century examined its role in hip...

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Bibliographic Details
Published in:The Journal of neuroscience 2023-11, Vol.43 (45), p.7538-7546
Main Authors: Kesner, Andrew J, Mozaffarilegha, Marjan, Thirtamara Rajamani, Keerthi, Arima, Yosuke, Harony-Nicolas, Hala, Hashimotodani, Yuki, Ito, Hiroshi T, Song, Juan, Ikemoto, Satoshi
Format: Article
Language:English
Subjects:
Circuits
Cognition
Cognitive ability
Hippocampal plasticity
Hippocampus
Hypothalamus
Hypothalamus (ventromedial)
Hypothalamus, Posterior
Memory
Motivation
Neurogenesis
Symposium and Mini-Symposium
Theta Rhythm
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Summary:The supramammillary nucleus (SuM) is a small region in the ventromedial posterior hypothalamus. The SuM has been relatively understudied with much of the prior focus being on its connection with septo-hippocampal circuitry. Thus, most studies conducted until the 21st century examined its role in hippocampal processes, such as theta rhythm and learning/memory. In recent years, the SuM has been "rediscovered" as a crucial hub for several behavioral and cognitive processes, including reward-seeking, exploration, and social memory. Additionally, it has been shown to play significant roles in hippocampal plasticity and adult neurogenesis. This review highlights findings from recent studies using cutting-edge systems neuroscience tools that have shed light on these fascinating roles for the SuM.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.1320-23.2023