Molecular characterization of the 2022 Sudan virus disease outbreak in Uganda

Ebola disease (EBOD) is a public health threat with a high case fatality rate. Most EBOD outbreaks have occurred in remote locations, but the 2013-2016 Western Africa outbreak demonstrated how devastating EBOD can be when it reaches an urban population. Here, the 2022 Sudan virus disease (SVD) outbr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of virology 2023-10, Vol.97 (10), p.e0059023-e0059023
Main Authors: Balinandi, Stephen, Whitmer, Shannon, Mulei, Sophia, Nassuna, Charity, Pimundu, Godfrey, Muyigi, Tonny, Kainulainen, Markus, Shedroff, Elizabeth, Krapiunaya, Inna, Scholte, Florine, Nyakarahuka, Luke, Tumusiime, Alex, Kyondo, Jackson, Baluku, Jimmy, Kiconco, Jocelyn, Harris, Julie R, Ario, Alex R, Kagirita, Atek, Bosa, Henry K, Ssewanyana, Isaac, Nabadda, Susan, Mwebesa, Henry G, Aceng, Jane R, Atwine, Diana, Lutwama, Julius J, Shoemaker, Trevor R, Montgomery, Joel M, Kaleebu, Pontiano, Klena, John D
Format: Article
Language:English
Subjects:
Contact Tracing
Disease Outbreaks - statistics & numerical data
Ebolavirus - chemistry
Ebolavirus - classification
Ebolavirus - genetics
Genetic Diversity and Evolution
Genetic Variation
Hemorrhagic Fever, Ebola - epidemiology
Hemorrhagic Fever, Ebola - transmission
Hemorrhagic Fever, Ebola - virology
Humans
Uganda - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ebola disease (EBOD) is a public health threat with a high case fatality rate. Most EBOD outbreaks have occurred in remote locations, but the 2013-2016 Western Africa outbreak demonstrated how devastating EBOD can be when it reaches an urban population. Here, the 2022 Sudan virus disease (SVD) outbreak in Mubende District, Uganda, is summarized, and the genetic relatedness of the new variant is evaluated. The Mubende variant exhibited 96% amino acid similarity with historic SUDV sequences from the 1970s and a high degree of conservation throughout the outbreak, which was important for ongoing diagnostics and highly promising for future therapy development. Genetic differences between viruses identified during the Mubende SVD outbreak were linked with epidemiological data to better interpret viral spread and contact tracing chains. This methodology should be used to better integrate discrete epidemiological and sequence data for future viral outbreaks.
ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.00590-23