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The institutional experience of the implementing 4DCT in NSCLC radiotherapy planning
BackgroundThe study was to evaluate the effectiveness of dose distribution of four-dimensional computed tomography (4DCT) simulation.Materials and methodsThe gross tumor volume (GTV) and clinical target volume (CTV) were contoured in all 10 respiratory phases of 4DCT in 30 patients with non-small ce...
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Published in: | Reports of practical oncology and radiotherapy 2023-01, Vol.28 (4), p.445-453 |
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creator | Dang, Huy Quang Nguyen, Cong Thanh Pham, Hoat Viet Tran, Linh Duc Nguyen, Cong Duc Truong, Dung Vu Manh Hoang, Trang Thi Kieu Chau, Tao Van |
description | BackgroundThe study was to evaluate the effectiveness of dose distribution of four-dimensional computed tomography (4DCT) simulation.Materials and methodsThe gross tumor volume (GTV) and clinical target volume (CTV) were contoured in all 10 respiratory phases of 4DCT in 30 patients with non-small cell lung cancer (NSCLC). Both 3D and 4D treatment plans were made individually for each patient using the planning volume (PTV). The PTV3D was taken from a single CTV plus the recommended margin, and the PTV4D was taken from the 4D internal target volume, including all 10 CTVs plus the setup margins.ResultsThe mean PTV was 460 ± 179 (69-820) cm3 for 3DCT and 401 ± 167 (127-854) cm3 for 4DCT (p = 0.0018). The dose distribution (DD) of organs at risk, especially the lungs, was lower for the 4DCT simulation. The V5%, V10%, and V20% of the total lung dose for 4DCT were significantly lower for the 3DCT. However, lung V30% the heart, esophagus, and spinal cord were not significantly different. In addition, the conformity index and the dose heterogeneity index of the PTV were not significantly different. The normal tissue complication probability (NTCP) of the lung and heart was significantly lower for 4DCT than for 3DCT.ConclusionsThe 4DCT simulation gives better results on the NTCP. The organs at risk, especially the lungs, receive a significantly lower DD compared with the 3DCT. The conformity index (CI), heterogeneity index (HI) and the DD to the heart, spinal cord, and esophagus were not significantly different between the two techniques. |
doi_str_mv | 10.5603/RPOR.a2023.0056 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10547414</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2873250861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c325t-2f107011dc1d0a8c08d4f1e40c2b3ed2b35ec1b8e71ac20a3b7cd8300d887783</originalsourceid><addsrcrecordid>eNpVUctOwzAQtBBIVKVnrjlySbu2k9g3hMJTqigquVuus2mN8sJOEf17HFohsYfdw8zOzmoIuaYwTzPgi_Xbaj3XDBifA6TZGZkwkDxOsgTOyYSmIGLKM3FJZt5_wFgCWCompCh2GNnWD3bYD7ZrdR3hd4_OYmsw6qpoGPGmr7HBdrDtNkru8yJsRK_v-TKPnC5tFzhO94eor3XbBs4Vuah07XF2mlNSPD4U-XO8XD295HfL2HCWDjGraLBBaWloCVoakGVSUUzAsA3HMrQUDd1IFFQbBppvhCklByilFELyKbk9yvb7TYOlCQadrlXvbKPdQXXaqv9Ia3dq230pCmkiEpoEhZuTgus-9-gH1VhvsA5_YLf3ikkRnILMaKAujlTjOu8dVn93KKgxAzVmoH4zUGMG_AdAT3tZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2873250861</pqid></control><display><type>article</type><title>The institutional experience of the implementing 4DCT in NSCLC radiotherapy planning</title><source>Open Access: PubMed Central</source><creator>Dang, Huy Quang ; Nguyen, Cong Thanh ; Pham, Hoat Viet ; Tran, Linh Duc ; Nguyen, Cong Duc ; Truong, Dung Vu Manh ; Hoang, Trang Thi Kieu ; Chau, Tao Van</creator><creatorcontrib>Dang, Huy Quang ; Nguyen, Cong Thanh ; Pham, Hoat Viet ; Tran, Linh Duc ; Nguyen, Cong Duc ; Truong, Dung Vu Manh ; Hoang, Trang Thi Kieu ; Chau, Tao Van</creatorcontrib><description>BackgroundThe study was to evaluate the effectiveness of dose distribution of four-dimensional computed tomography (4DCT) simulation.Materials and methodsThe gross tumor volume (GTV) and clinical target volume (CTV) were contoured in all 10 respiratory phases of 4DCT in 30 patients with non-small cell lung cancer (NSCLC). Both 3D and 4D treatment plans were made individually for each patient using the planning volume (PTV). The PTV3D was taken from a single CTV plus the recommended margin, and the PTV4D was taken from the 4D internal target volume, including all 10 CTVs plus the setup margins.ResultsThe mean PTV was 460 ± 179 (69-820) cm3 for 3DCT and 401 ± 167 (127-854) cm3 for 4DCT (p = 0.0018). The dose distribution (DD) of organs at risk, especially the lungs, was lower for the 4DCT simulation. The V5%, V10%, and V20% of the total lung dose for 4DCT were significantly lower for the 3DCT. However, lung V30% the heart, esophagus, and spinal cord were not significantly different. In addition, the conformity index and the dose heterogeneity index of the PTV were not significantly different. The normal tissue complication probability (NTCP) of the lung and heart was significantly lower for 4DCT than for 3DCT.ConclusionsThe 4DCT simulation gives better results on the NTCP. The organs at risk, especially the lungs, receive a significantly lower DD compared with the 3DCT. The conformity index (CI), heterogeneity index (HI) and the DD to the heart, spinal cord, and esophagus were not significantly different between the two techniques.</description><identifier>ISSN: 1507-1367</identifier><identifier>EISSN: 2083-4640</identifier><identifier>DOI: 10.5603/RPOR.a2023.0056</identifier><language>eng</language><publisher>Via Medica</publisher><subject>Research Paper</subject><ispartof>Reports of practical oncology and radiotherapy, 2023-01, Vol.28 (4), p.445-453</ispartof><rights>2023 Greater Poland Cancer Centre 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547414/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547414/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids></links><search><creatorcontrib>Dang, Huy Quang</creatorcontrib><creatorcontrib>Nguyen, Cong Thanh</creatorcontrib><creatorcontrib>Pham, Hoat Viet</creatorcontrib><creatorcontrib>Tran, Linh Duc</creatorcontrib><creatorcontrib>Nguyen, Cong Duc</creatorcontrib><creatorcontrib>Truong, Dung Vu Manh</creatorcontrib><creatorcontrib>Hoang, Trang Thi Kieu</creatorcontrib><creatorcontrib>Chau, Tao Van</creatorcontrib><title>The institutional experience of the implementing 4DCT in NSCLC radiotherapy planning</title><title>Reports of practical oncology and radiotherapy</title><description>BackgroundThe study was to evaluate the effectiveness of dose distribution of four-dimensional computed tomography (4DCT) simulation.Materials and methodsThe gross tumor volume (GTV) and clinical target volume (CTV) were contoured in all 10 respiratory phases of 4DCT in 30 patients with non-small cell lung cancer (NSCLC). Both 3D and 4D treatment plans were made individually for each patient using the planning volume (PTV). The PTV3D was taken from a single CTV plus the recommended margin, and the PTV4D was taken from the 4D internal target volume, including all 10 CTVs plus the setup margins.ResultsThe mean PTV was 460 ± 179 (69-820) cm3 for 3DCT and 401 ± 167 (127-854) cm3 for 4DCT (p = 0.0018). The dose distribution (DD) of organs at risk, especially the lungs, was lower for the 4DCT simulation. The V5%, V10%, and V20% of the total lung dose for 4DCT were significantly lower for the 3DCT. However, lung V30% the heart, esophagus, and spinal cord were not significantly different. In addition, the conformity index and the dose heterogeneity index of the PTV were not significantly different. The normal tissue complication probability (NTCP) of the lung and heart was significantly lower for 4DCT than for 3DCT.ConclusionsThe 4DCT simulation gives better results on the NTCP. The organs at risk, especially the lungs, receive a significantly lower DD compared with the 3DCT. The conformity index (CI), heterogeneity index (HI) and the DD to the heart, spinal cord, and esophagus were not significantly different between the two techniques.</description><subject>Research Paper</subject><issn>1507-1367</issn><issn>2083-4640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpVUctOwzAQtBBIVKVnrjlySbu2k9g3hMJTqigquVuus2mN8sJOEf17HFohsYfdw8zOzmoIuaYwTzPgi_Xbaj3XDBifA6TZGZkwkDxOsgTOyYSmIGLKM3FJZt5_wFgCWCompCh2GNnWD3bYD7ZrdR3hd4_OYmsw6qpoGPGmr7HBdrDtNkru8yJsRK_v-TKPnC5tFzhO94eor3XbBs4Vuah07XF2mlNSPD4U-XO8XD295HfL2HCWDjGraLBBaWloCVoakGVSUUzAsA3HMrQUDd1IFFQbBppvhCklByilFELyKbk9yvb7TYOlCQadrlXvbKPdQXXaqv9Ia3dq230pCmkiEpoEhZuTgus-9-gH1VhvsA5_YLf3ikkRnILMaKAujlTjOu8dVn93KKgxAzVmoH4zUGMG_AdAT3tZ</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Dang, Huy Quang</creator><creator>Nguyen, Cong Thanh</creator><creator>Pham, Hoat Viet</creator><creator>Tran, Linh Duc</creator><creator>Nguyen, Cong Duc</creator><creator>Truong, Dung Vu Manh</creator><creator>Hoang, Trang Thi Kieu</creator><creator>Chau, Tao Van</creator><general>Via Medica</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230101</creationdate><title>The institutional experience of the implementing 4DCT in NSCLC radiotherapy planning</title><author>Dang, Huy Quang ; Nguyen, Cong Thanh ; Pham, Hoat Viet ; Tran, Linh Duc ; Nguyen, Cong Duc ; Truong, Dung Vu Manh ; Hoang, Trang Thi Kieu ; Chau, Tao Van</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-2f107011dc1d0a8c08d4f1e40c2b3ed2b35ec1b8e71ac20a3b7cd8300d887783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dang, Huy Quang</creatorcontrib><creatorcontrib>Nguyen, Cong Thanh</creatorcontrib><creatorcontrib>Pham, Hoat Viet</creatorcontrib><creatorcontrib>Tran, Linh Duc</creatorcontrib><creatorcontrib>Nguyen, Cong Duc</creatorcontrib><creatorcontrib>Truong, Dung Vu Manh</creatorcontrib><creatorcontrib>Hoang, Trang Thi Kieu</creatorcontrib><creatorcontrib>Chau, Tao Van</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reports of practical oncology and radiotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dang, Huy Quang</au><au>Nguyen, Cong Thanh</au><au>Pham, Hoat Viet</au><au>Tran, Linh Duc</au><au>Nguyen, Cong Duc</au><au>Truong, Dung Vu Manh</au><au>Hoang, Trang Thi Kieu</au><au>Chau, Tao Van</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The institutional experience of the implementing 4DCT in NSCLC radiotherapy planning</atitle><jtitle>Reports of practical oncology and radiotherapy</jtitle><date>2023-01-01</date><risdate>2023</risdate><volume>28</volume><issue>4</issue><spage>445</spage><epage>453</epage><pages>445-453</pages><issn>1507-1367</issn><eissn>2083-4640</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>BackgroundThe study was to evaluate the effectiveness of dose distribution of four-dimensional computed tomography (4DCT) simulation.Materials and methodsThe gross tumor volume (GTV) and clinical target volume (CTV) were contoured in all 10 respiratory phases of 4DCT in 30 patients with non-small cell lung cancer (NSCLC). Both 3D and 4D treatment plans were made individually for each patient using the planning volume (PTV). The PTV3D was taken from a single CTV plus the recommended margin, and the PTV4D was taken from the 4D internal target volume, including all 10 CTVs plus the setup margins.ResultsThe mean PTV was 460 ± 179 (69-820) cm3 for 3DCT and 401 ± 167 (127-854) cm3 for 4DCT (p = 0.0018). The dose distribution (DD) of organs at risk, especially the lungs, was lower for the 4DCT simulation. The V5%, V10%, and V20% of the total lung dose for 4DCT were significantly lower for the 3DCT. However, lung V30% the heart, esophagus, and spinal cord were not significantly different. In addition, the conformity index and the dose heterogeneity index of the PTV were not significantly different. The normal tissue complication probability (NTCP) of the lung and heart was significantly lower for 4DCT than for 3DCT.ConclusionsThe 4DCT simulation gives better results on the NTCP. The organs at risk, especially the lungs, receive a significantly lower DD compared with the 3DCT. The conformity index (CI), heterogeneity index (HI) and the DD to the heart, spinal cord, and esophagus were not significantly different between the two techniques.</abstract><pub>Via Medica</pub><doi>10.5603/RPOR.a2023.0056</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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title | The institutional experience of the implementing 4DCT in NSCLC radiotherapy planning |
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