The institutional experience of the implementing 4DCT in NSCLC radiotherapy planning

BackgroundThe study was to evaluate the effectiveness of dose distribution of four-dimensional computed tomography (4DCT) simulation.Materials and methodsThe gross tumor volume (GTV) and clinical target volume (CTV) were contoured in all 10 respiratory phases of 4DCT in 30 patients with non-small ce...

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Published in:Reports of practical oncology and radiotherapy 2023-01, Vol.28 (4), p.445-453
Main Authors: Dang, Huy Quang, Nguyen, Cong Thanh, Pham, Hoat Viet, Tran, Linh Duc, Nguyen, Cong Duc, Truong, Dung Vu Manh, Hoang, Trang Thi Kieu, Chau, Tao Van
Format: Article
Language:English
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Summary:BackgroundThe study was to evaluate the effectiveness of dose distribution of four-dimensional computed tomography (4DCT) simulation.Materials and methodsThe gross tumor volume (GTV) and clinical target volume (CTV) were contoured in all 10 respiratory phases of 4DCT in 30 patients with non-small cell lung cancer (NSCLC). Both 3D and 4D treatment plans were made individually for each patient using the planning volume (PTV). The PTV3D was taken from a single CTV plus the recommended margin, and the PTV4D was taken from the 4D internal target volume, including all 10 CTVs plus the setup margins.ResultsThe mean PTV was 460 ± 179 (69-820) cm3 for 3DCT and 401 ± 167 (127-854) cm3 for 4DCT (p = 0.0018). The dose distribution (DD) of organs at risk, especially the lungs, was lower for the 4DCT simulation. The V5%, V10%, and V20% of the total lung dose for 4DCT were significantly lower for the 3DCT. However, lung V30% the heart, esophagus, and spinal cord were not significantly different. In addition, the conformity index and the dose heterogeneity index of the PTV were not significantly different. The normal tissue complication probability (NTCP) of the lung and heart was significantly lower for 4DCT than for 3DCT.ConclusionsThe 4DCT simulation gives better results on the NTCP. The organs at risk, especially the lungs, receive a significantly lower DD compared with the 3DCT. The conformity index (CI), heterogeneity index (HI) and the DD to the heart, spinal cord, and esophagus were not significantly different between the two techniques.
ISSN:1507-1367
2083-4640
DOI:10.5603/RPOR.a2023.0056