Effect of Central Sensitization in Patients with Familial Mediterranean Fever, Axial Spondyloarthritis, and Both Diseases

Objective: Our aim in this study was to evaluate the level of central sensitization (CS) in patients having familial Mediterranean fever (FMF), axial spondyloarthritis (axSpA), and both diseases (axSpA/FMF).Methods: This study included 30 FMF, 30 axSpA, 30 axSpA/FMF patients, and 30 healthy controls...

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Published in:Curēus (Palo Alto, CA) CA), 2023-09, Vol.15 (9), p.e45459-e45459
Main Authors: Kaya, Mehmet Nur, Kılıç, Özlem, Doğan, Abdullah, Yılmaz, Sedat, Tecer, Duygu
Format: Article
Language:English
Subjects:
Amyloidosis
Arthritis
Disease
Fever
Inflammation
Internal Medicine
Nervous system
Nonsteroidal anti-inflammatory drugs
Pain
Patients
Quality of life
Questionnaires
Rheumatology
Sleep
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Summary:Objective: Our aim in this study was to evaluate the level of central sensitization (CS) in patients having familial Mediterranean fever (FMF), axial spondyloarthritis (axSpA), and both diseases (axSpA/FMF).Methods: This study included 30 FMF, 30 axSpA, 30 axSpA/FMF patients, and 30 healthy controls (HCs). The presence of CS was investigated by the Central Sensitization Inventory (CSI) questionnaire. In order to evaluate the effect of CS on patient groups, clinical features, disease activity, quality of life, sleep quality, depression, and anxiety frequency were examined. The patients were divided into groups according to the presence and severity of CS and their results were compared.Results: The mean age of all participants was 28.4±5.7 years and 67 (55.8%) of them were male. The erythrocyte sedimentation rate (ESR) value was significantly higher in axSpA and axSpA/FMF groups than in FMF and HCs groups (p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.45459