Impact of analysis of the sentinel lymph node by one-step nucleic acid amplification (OSNA) compared to conventional histopathology on axillary and systemic treatment: data from the Dutch nationwide cohort of breast cancer patients

Purpose The outcome of the sentinel lymph node in breast cancer patients affects adjuvant treatment. Compared to conventional histopathology, analysis by one-step nucleic acid amplification (OSNA) harvests more micrometastasis, potentially inducing overtreatment. In this study we investigated the im...

Full description

Saved in:
Bibliographic Details
Published in:Breast cancer research and treatment 2023-11, Vol.202 (2), p.245-255
Main Authors: van Haaren, Elisabeth R. M., Poodt, Ingrid G. M., Spiekerman van Weezelenburg, Merel A., van Bastelaar, James, Janssen, Alfred, de Vries, Bart, Lobbes, Marc B. I., Bouwman, Lee H., Vissers, Yvonne L. J.
Format: Article
Language:English
Subjects:
Breast cancer
Cancer research
Cancer therapies
Chemotherapy
Clinical Trial
Endocrine therapy
Histology
Histopathology
Lymph nodes
Lymphatic system
Mastectomy
Medicine
Medicine & Public Health
Oncology
Patients
Radiation therapy
Statistical analysis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The outcome of the sentinel lymph node in breast cancer patients affects adjuvant treatment. Compared to conventional histopathology, analysis by one-step nucleic acid amplification (OSNA) harvests more micrometastasis, potentially inducing overtreatment. In this study we investigated the impact of OSNA analysis on adjuvant treatment, compared to histopathological analysis. Methods Data from T1–3 breast cancer patients with sentinel nodes analysed between January 2016 and December 2019 by OSNA (OSNA group, n  = 1086) from Zuyderland Medical Centre, the Netherlands, were compared to concurrent data from the Netherlands Cancer Registry (NKR) where sentinel nodes were examined by histology (histology group, n = 35,143). Primary outcomes were micro- or macrometastasis, axillary treatments (axillary lymph node dissection (ALND) or axillary radiotherapy (ART)), chemotherapy, and endocrine therapy. Statistics with Pearson Chi-square. Results In the OSNA group more micrometastasis (14.9%) were detected compared to the histology group (7.9%, p  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-023-07065-0