The GPx-1 Gene Variants (rs1050450) in Obesity: Association with the Risk of Obesity and the GPx Activity in Females

BackgroundThis study aimed to investigate the GPx-1 gene polymorphism (rs1050450), the level of oxidative stress and antioxidant parameters, and the lipid profile in an obese Kurdish population in Sulaimani, Iraq. MethodsIn a case-control study,134 obese subjects and 131 normal BMI healthy individua...

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Published in:Reports of biochemistry and molecular biology 2023-04, Vol.12 (1), p.185-194
Main Authors: Ahmad, Avan Arif, Rahimi, Zohreh, Asadi, Soheila, Vaisi-Raygani, Asad, Kohsari, Maryam
Format: Article
Language:English
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Summary:BackgroundThis study aimed to investigate the GPx-1 gene polymorphism (rs1050450), the level of oxidative stress and antioxidant parameters, and the lipid profile in an obese Kurdish population in Sulaimani, Iraq. MethodsIn a case-control study,134 obese subjects and 131 normal BMI healthy individuals participated. The GPx-1 gene polymorphism was assessed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The levels of biochemical and oxidative parameters were determined using photometric methods. ResultsThe results showed that the fasting blood sugar (FBS), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher in obese subjects compared to the control group. Obese individuals had significantly lower levels of high-density lipoprotein cholesterol (HDL-C) than the controls. The GPx-1 activity and total antioxidant capacity (TAC) levels were significantly elevated in the obese group compared to the control group (P=0.006, and P
ISSN:2322-3480
2322-3480
DOI:10.52547/rbmb.12.1.185