Maximizing flow rate in single paper layer, rapid flow microfluidic paper-based analytical devices

Small, single-layer microfluidic paper-based analytical devices (µPADs) offer potential for a range of point-of-care applications; however, they have been limited to low flow rates. Here, we investigate the role of laser cutting paper channels in maximizing flow rate in small profile devices with li...

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Bibliographic Details
Published in:Microfluidics and nanofluidics 2023-10, Vol.27 (10), p.70-70, Article 70
Main Authors: Macleod Briongos, Iain, Call, Zachary D., Henry, Charles S., Bark, David L.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biomedical engineering
Biomedical Engineering and Bioengineering
Channels
Design
Devices
Engineering
Engineering Fluid Dynamics
Flow rates
Flow velocity
Grooves
Laser beam cutting
Lasers
Low flow
Maximization
Microfluidic devices
Nanotechnology and Microengineering
Optimization
Rapid flow
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Summary:Small, single-layer microfluidic paper-based analytical devices (µPADs) offer potential for a range of point-of-care applications; however, they have been limited to low flow rates. Here, we investigate the role of laser cutting paper channels in maximizing flow rate in small profile devices with limited fluid volumes. We demonstrate that branching, laser-cut grooves can provide a 59.23–73.98% improvement in flow rate over a single cut, and a 435% increase over paper alone. These design considerations can be applied to more complex microfluidic devices with the aim of increasing the flow rate, and could be used in stand-alone channels for self-pumping.
ISSN:1613-4982
1613-4990
DOI:10.1007/s10404-023-02679-8