Krebs von den Lungen-6 (KL-6) in cerebrospinal fluid from neurosarcoidosis patients

Krebs von den Lungen-6 (KL-6) is a high molecular weight (MW) glycoprotein mainly secreted by type II pneumocytes because of lung damage or during regeneration. Neurosarcoidosis (NS), where sarcoid granulomas involve the nervous system, occurs in 5-20% of patients with sarcoidosis. No data is curren...

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Published in:Sarcoidosis, vasculitis, and diffuse lung diseases vasculitis, and diffuse lung diseases, 2023-06, Vol.40 (2), p.e2023019-e2023019
Main Authors: Bocci, Silvia, D'Alessandro, Miriana, Bergantini, Laura, Cerase, Alfonso, Ulivelli, Monica, Rottoli, Paola, Cavallaro, Dalila, Gangi, Sara, Bargagli, Elena, Giannini, Fabio
Format: Article
Language:English
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Summary:Krebs von den Lungen-6 (KL-6) is a high molecular weight (MW) glycoprotein mainly secreted by type II pneumocytes because of lung damage or during regeneration. Neurosarcoidosis (NS), where sarcoid granulomas involve the nervous system, occurs in 5-20% of patients with sarcoidosis. No data is currently available on KL-6 in serum or CSF of NS patients. The present study compared KL-6 concentrations in serum and CSF of NS patients versus others with neurodegenerative (ND) or chronic inflammatory demyelinating (DM) diseases. Nine NS patients (mean age 46.2 years, range 16-61 years, M/F 5/4), nine patients with a chronic neurodegenerative disease (mean age 53.1 years, range 37-65 years, M/F 5/4) and nine patients with a chronic demyelinating disease (mean age 46.3 years, range 18-65 years, M/F 5/4) were retrospectively enrolled. Measurable CSF concentrations of KL-6 were detected in 7/9 NS patients but in no ND or DM patients. No significant differences in CSF concentrations of ACE were observed between the three groups (p=0.0819). In NS patients, CSF concentrations of KL-6 were directly correlated with CSF albumin index (r=0.98; p
ISSN:1124-0490
2532-179X
DOI:10.36141/svdld.v40i2.12900