The protective effect of roflumilast and ibuprofen on testicular ischemia reperfusion injury: An experimental study

The aim of the present study is to investigate the efficiency of roflumilast and ibuprofen in an experimental rat testicular ischemia reperfusion injury model in the light of histological and biochemical data. A total of 32 prepubertal male rats were randomly divided into four groups as G1: Control...

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Bibliographic Details
Published in:Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 2022-06, Vol.28 (6), p.730-735
Main Authors: Özgür, Berat Cem, Surer, Hatice, Yücetürk, Cem Nedim, Karakan, Tolga, Özer, Elif, Ogus, Elmas
Format: Article
Language:English
Subjects:
Aminopyridines
Animals
Benzamides
Cyclopropanes
Experimental Study
Humans
Ibuprofen - pharmacology
Male
Rats
Reperfusion Injury - drug therapy
Reperfusion Injury - pathology
Reperfusion Injury - prevention & control
Spermatic Cord Torsion - drug therapy
Testis - pathology
Thyrotropin - pharmacology
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Summary:The aim of the present study is to investigate the efficiency of roflumilast and ibuprofen in an experimental rat testicular ischemia reperfusion injury model in the light of histological and biochemical data. A total of 32 prepubertal male rats were randomly divided into four groups as G1: Control Group (testicular torsion/detorsion + saline (0.9% of 2 ml) was applied). G2: Sham Group only right scrotal incision was performed; G3: Ibuprofen Group (tes-ticular torsion/detorsion + ibuprofen administration); and G4 Roflumilast Group (testicular torsion/detorsion + roflumilast adminis-tration). Oxidative markers such as malondialdehyde (MDA), myeloperoxidase (MPO), total sulfhydryl (TSH), and nitrite (NO) levels as well as histopathological changes were analyzed. Tissue MPO, MDA, and NO levels were significantly higher and TSH levels significantly lower in control group compared to sham group (p
ISSN:1306-696X
1307-7945
DOI:10.14744/tjtes.2021.01361