Optically amended biosynthesized crystalline copper-doped ZnO for enhanced antibacterial activity

The emergence and re-emergence of antibiotic-resistant bacteria is a potential threat to treating infectious diseases. This study employed a nanometer-scale green synthesis using an extract of Solanum incanum leaves to obtain nanoparticles (NPs) and nanocomposites (NCs) possessing antibacterial prop...

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Bibliographic Details
Published in:RSC advances 2023-08, Vol.13 (35), p.24835-24845
Main Authors: Mengistu, Adam, Naimuddin, Mohammed, Abebe, Buzuayehu
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Charge transfer
Chemistry
Copper
Copper oxides
Crystal lattices
Dopants
Doping
Drug resistance
Free radicals
Heterojunctions
Infectious diseases
Nanocomposites
Nanoparticles
Optical properties
Pattern analysis
Scavenging
Synergistic effect
Synthesis
Zinc oxide
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Summary:The emergence and re-emergence of antibiotic-resistant bacteria is a potential threat to treating infectious diseases. This study employed a nanometer-scale green synthesis using an extract of Solanum incanum leaves to obtain nanoparticles (NPs) and nanocomposites (NCs) possessing antibacterial properties. The FESEM-EDS elemental mapping analysis proved the novelty of the green synthesis approach in synthesizing a copper-doped ZnO NCs with good dopant distribution. The crystallinity and ZnO bandgap were adjusted by extrinsic copper doping in the ZnO lattice. The optical property adjustments from 3.04 to 2.97 eV for indirect Kubelka-Munk functions were confirmed from DRS-UV-vis analysis. The dopant inclusion in the host lattice was also confirmed by the angle shift on the XRD pattern analysis relative to single ZnO. In addition to doping, the XRD pattern analysis also showed the development of CuO crystals. The lattice fringe values from HRTEM analysis confirmed the existence of both CuO and ZnO crystals with local heterojunctions. Doping and heterojunctions have crucial values in charge transfer and visible light harvesting behaviour, as proved by the PL analysis. The synergistic effects of the doped NCs showed greater antibacterial activity against both Gram-positive and Gram-negative bacteria as a result of more ROS generation through the bacteria-cell-catalyst interaction and release of metal ions. The antioxidant potential of the doped NCs was found to be higher than that of single NPs, using the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay and is expected to impart protective effects to the host cells by scavenging destructive free radicals. Thus, the overall analysis leads to the conclusion that the potentiality of synthesized materials has a future outlook for biological applications, especially in the development of antimicrobials to combat antibiotic-resistant bacteria and microbes. Green synthesis approach-based synthesis of nanoscale-sized doped nanocomposites for enhanced antibacterial activity.
ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra04488b