Five-Year Prognostic Value of DAPT Score in Older Patients undergoing Percutaneous Coronary Intervention: A Large-Sample Study in the Real World

Aim: The dual-antiplatelet therapy (DAPT) score is recommended for predicting the risk of ischemia and bleeding for patients undergoing percutaneous coronary intervention (PCI). This study aimed to investigate the long-term prognostic value of the DAPT score in older PCI patients.Methods: This study...

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Published in:	Journal of Atherosclerosis and Thrombosis 2023/08/01, Vol.30(8), pp.1057-1069
Main Authors:	Yan, Kailun, Zhu, Pei, Tang, Xiaofang, Li, Yulong, Li, Jiawen, Yuan, Deshan, Yang, Weixian, Yang, Yuejin, Gao, Runlin, Xu, Bo, Yuan, Jinqing, Zhao, Xueyan
Format:	Article
Language:	eng ; jpn
Subjects:	Aged bleeding DAPT score Drug Therapy, Combination Dual Anti-Platelet Therapy - adverse effects Hemorrhage - chemically induced Humans Ischemia - etiology MACCE Myocardial Infarction - etiology older Original PCI Percutaneous Coronary Intervention - adverse effects Platelet Aggregation Inhibitors - adverse effects Prognosis Treatment Outcome
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Summary:	Aim: The dual-antiplatelet therapy (DAPT) score is recommended for predicting the risk of ischemia and bleeding for patients undergoing percutaneous coronary intervention (PCI). This study aimed to investigate the long-term prognostic value of the DAPT score in older PCI patients.Methods: This study enrolled 10,724 consecutive patients who underwent PCI from January 2013 to December 2013 in Fu Wai hospital, among whom 2,981 (27.8%) were aged ≥ 65 years. The ischemic endpoint was major adverse cardiovascular and cerebrovascular events (MACCE, including myocardial infarction, all-cause death, and stroke). The bleeding endpoint was Bleeding Academic Research Consortium (BARC) 2, 3, or 5 bleeding.Results: After a 5-year follow-up, 256 (12.0%) MACCEs and 53 (2.5%) BARC 2, 3, or 5 bleeding occurred. The patients were divided into two groups according to the DAPT score: the low-score (＜2, n=1,646) and high-score (≥ 2, n=485) group. Multivariate Cox regression revealed that the risk of MACCE was similar between the two groups [hazard ratio (HR): 1.214, 95% confidence interval (CI): 0.916–1.609, P=0.178], whereas the risk of bleeding was significantly higher in the high-score group than in the low-score group (HR: 2.447, 95% CI: 1.407–4.257, P=0.002). The DAPT score did not show prognostic value in MACCE [area under the receiver operating characteristic curve (AUROC), 0.534; 95% CI: 0.496–0.572, P=0.079]; however, it demonstrated a certain prognostic value in BARC 2, 3, or 5 bleeding (AUROC, 0.646; 95% CI: 0.573–0.719, P＜0.001).Conclusion: This study suggested that in older PCI patients, the DAPT score did not show predictive value for MACCE; however, it had a certain predictive value for 5-year BARC 2, 3, or 5 bleeding.
ISSN:	1340-3478 1880-3873