Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China

The new term essential tremor (ET) plus was proposed in the 2018 tremor consensus criteria. The National Survey of Essential Tremor Plus in China, a large multicenter registry study, aimed to evaluate the clinical features of pure ET and ET plus and explore possible factors related to ET plus. All p...

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Published in:Aging and disease 2023-08, Vol.14 (4), p.1360-1373
Main Authors: Sun, Qiying, He, Runcheng, Huang, Hongyan, Cao, Hongmei, Wang, Xuejing, Liu, Hong, Wang, Chunyu, Lei, Lifang, Wang, Puqing, Cui, Guiyun, Ma, Jianjun, Gu, Ping, An, Di, Jia, Min, Sun, Zhanfang, Wu, Heng, Lin, Jinsheng, Tang, Jiayu, Zhou, Xun, Li, Mingqiang, Zeng, Sheng, Chen, Yase, Yan, Xinxiang, Guo, Jifeng, Xu, Qian, Liu, Zhenhua, Shen, Lu, Jiang, Hong, Wu, Xinyin, Xiao, Qin, Chen, Haibo, Xu, Yanming, Tang, Beisha
Format: Article
Language:English
Subjects:
Diagnosis
Original
Surveys
Tremor
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Summary:The new term essential tremor (ET) plus was proposed in the 2018 tremor consensus criteria. The National Survey of Essential Tremor Plus in China, a large multicenter registry study, aimed to evaluate the clinical features of pure ET and ET plus and explore possible factors related to ET plus. All patients with ET underwent neurological examination and neuropsychological assessment at 17 clinical sites. The diagnosis was made according to the 2018 consensus criteria. Clinicodemographic characteristics were analyzed. A total of 1160 patients were included, including 546 patients with pure ET and 614 patients with ET plus. The proportion of females was significantly higher in the ET plus than that in the pure ET (P = 0.001). The age at onset (AAO) of pure ET showed a bimodal distribution, with peaks in the 2nd and 5th decades. However, the AAO of the ET plus group demonstrated a skewed distribution, with a single peak in the 6th decade. Female sex (OR=1.645, P
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2022.1205