Correlation between the CT Perfusion Parameter Values and Response to Recanalization in Patients with Acute Ischemic Stroke

Objective: CT perfusion (CTP) provides various hemodynamic parameters. However, it is unclear which CTP parameters are useful in predicting clinical outcome in patients with acute ischemic stroke (AIS).Methods: Between February 2019 and June 2021, patients with anterior circulation large-vessel occl...

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Published in:Journal of Neuroendovascular Therapy 2022, Vol.16(12), pp.577-585
Main Authors: Hirai, Sakyo, Sato, Hirotaka, Yamamura, Toshihiro, Kato, Koichi, Ishikawa, Mariko, Sagawa, Hirotaka, Aoyama, Jiro, Fujii, Shoko, Fujita, Kyohei, Arai, Toshinari, Sumita, Kazutaka
Format: Article
Language:English
Subjects:
acute ischemic stroke
Bayesian Vitrea
cerebral perfusion parameter
CT perfusion
mechanical thrombectomy
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Summary:Objective: CT perfusion (CTP) provides various hemodynamic parameters. However, it is unclear which CTP parameters are useful in predicting clinical outcome in patients with acute ischemic stroke (AIS).Methods: Between February 2019 and June 2021, patients with anterior circulation large-vessel occlusion who achieved successful recanalization within 8 hours after stroke onset were included. The relative CTP parameter values analyzed by the reformulated singular value decomposition (SVD) method in the affected middle cerebral artery territories compared to those in the unaffected side were calculated. In addition, the ischemic core volume (ICV) was evaluated using a Bayesian Vitrea. The final infarct volume (FIV) was assessed by 24-hour MRI. The correlation between these CTP-derived values and clinical outcome was assessed.Results: Forty-two patients were analyzed. Among the CTP-related parameters, the ICV, relative cerebral blood volume (rCBV), and relative mean transit time (rMTT) showed a strong correlation with the FIV (ρ = 0.74, p
ISSN:1882-4072
2186-2494
DOI:10.5797/jnet.oa.2022-0026