Aberrant intra‐ and internetwork functional connectivity patterns of the anterior and posterior hippocampal networks in schizophrenia

Aim Schizophrenia is associated with abnormal hippocampal structure and function. Available evidence suggests that the anterior and posterior hippocampus are differentially affected by schizophrenia pathology. This study was designed to provide new insight into the anterior and posterior hippocampus...

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Published in:	CNS neuroscience & therapeutics 2023-08, Vol.29 (8), p.2223-2235
Main Authors:	Li, Xin‐Wei, Liu, Hong, Deng, Yuan‐Yang, Li, Zhang‐Yong, Jiang, Yu‐Hao, Li, De‐Yu, Li, Shu‐Yu
Format:	Article
Language:	eng
Subjects:	Alzheimer's disease Brain - pathology Brain Mapping Brain research Cognition & reasoning Functional magnetic resonance imaging hippocampal segments Hippocampus Hippocampus - diagnostic imaging Humans internetwork intranetwork Magnetic resonance imaging Magnetic Resonance Imaging - methods Memory Mental disorders Neural Pathways - diagnostic imaging Original Pathology Problem solving resting‐state functional connectivity Schizophrenia Schizophrenia - diagnostic imaging Structure-function relationships Verbal learning
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Summary:	Aim Schizophrenia is associated with abnormal hippocampal structure and function. Available evidence suggests that the anterior and posterior hippocampus are differentially affected by schizophrenia pathology. This study was designed to provide new insight into the anterior and posterior hippocampus in schizophrenia from the perspective of functional connectivity. Methods Based on resting‐state functional magnetic resonance imaging data of 71 schizophrenia patients and 74 normal controls, we utilized a data‐driven approach to functionally segment the hippocampus into anterior and posterior segments and then investigated the functional connectivity patterns within and between the two hippocampal networks at the network, edge, and nodal levels. Results We found that schizophrenia patients showed hyperconnectivity of both the anterior and posterior hippocampal networks. We also observed that the network alterations appear somewhat greater in the anterior hippocampal network than the posterior network, the left side than the right, and the intranetwork connectivity than the internetwork connectivity. Conclusion The results reveal convergent and divergent intranetwork and internetwork connectivity patterns of the anterior and posterior hippocampus in schizophrenia, providing novel and important insights into the mechanisms of hippocampal pathology in schizophrenia. The anterior and posterior hippocampal networks in schizophrenia showed convergent and divergent intranetwork and internetwork connectivity patterns, at the network, edge, and nodal levels.
ISSN:	1755-5930 1755-5949