Rottlerin suppresses lipid accumulation by inhibiting de novo lipogenesis and adipogenesis via LRP6/mTOR/SREBP1C in 3T3-L1 adipocytes

Rottlerin is isolated from Mallotus japonicus , a plant rich in polyphenols. Rottlerin is a selective PKCδ-inhibitor and is also known as an uncoupler of oxidative phosphorylation and anti-neoplastic agent. However, its anti-obesity effect is yet to be established. Therefore, this study tested wheth...

Full description

Saved in:
Bibliographic Details
Published in:Food science and biotechnology 2023-09, Vol.32 (10), p.1445-1452
Main Authors: Kim, Yejin, Kim, Hyun Kyung, Kang, Sumin, Kim, Hayoon, Go, Gwang-woong
Format: Article
Language:English
Subjects:
Accumulation
Adipocytes
Adipogenesis
AKT protein
Chemistry
Chemistry and Materials Science
Food Science
Lipids
Lipogenesis
mRNA
Nutrition
Oxidative phosphorylation
Phenotypes
Phosphorylation
Polyphenols
Protein kinase C
Proteins
Research Article
TOR protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rottlerin is isolated from Mallotus japonicus , a plant rich in polyphenols. Rottlerin is a selective PKCδ-inhibitor and is also known as an uncoupler of oxidative phosphorylation and anti-neoplastic agent. However, its anti-obesity effect is yet to be established. Therefore, this study tested whether rottlerin inhibits adipogenesis and de novo lipogenesis via the LRP6/mTOR/SREBP1C pathway in 3T3-L1 adipocytes. Rottlerin dramatically decreased lipid accumulation assessed by Oil Red O as evidence to support the cellular phenotype ( p  
ISSN:1226-7708
2092-6456
2092-6456
DOI:10.1007/s10068-023-01339-5