Aortitis Associated with Prophylactic Short-acting Granulocyte Colony-stimulating Factor Administration: A Case Report and Review of the Literature

We herein report an 83-year-old woman with filgrastim-associated aortitis during chemotherapy for relapsed diffuse large B-cell lymphoma. She had been treated with filgrastim as a prophylaxis for neutropenia during the fourth cycle of chemotherapy from day 9 to 18. On day 21, she developed a fever....

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Bibliographic Details
Published in:Internal Medicine 2023/06/01, Vol.62(11), pp.1647-1652
Main Authors: Masuda, Yasutaka, Oyama, Takashi, Nakazaki, Kumi, Nakai, Yudai, Sasaki, Ken, Matsuda, Kensuke, Masamoto, Yosuke, Kurokawa, Mineo
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Aorta
aortitis
Aortitis - chemically induced
Aortitis - diagnostic imaging
Aortitis - drug therapy
B-cell lymphoma
Case Report
Chemotherapy
Colonies
Colony-stimulating factor
Computed tomography
Female
Fever
Fever - drug therapy
Filgrastim - adverse effects
Granulocyte colony-stimulating factor
Granulocyte Colony-Stimulating Factor - adverse effects
Humans
Inflammation
Internal medicine
Leukocytes (granulocytic)
Literature reviews
long-acting G-CSF
Lymphocytes B
Neoplasms - drug therapy
Neutropenia
Neutropenia - drug therapy
non-Hodgkin lymphoma
Nonsteroidal anti-inflammatory drugs
prophylactic treatment
Prophylaxis
short-acting G-CSF
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Summary:We herein report an 83-year-old woman with filgrastim-associated aortitis during chemotherapy for relapsed diffuse large B-cell lymphoma. She had been treated with filgrastim as a prophylaxis for neutropenia during the fourth cycle of chemotherapy from day 9 to 18. On day 21, she developed a fever. Contrast-enhanced computed tomography revealed aortitis of the descending aorta. The fever abated with non-steroidal anti-inflammatory drug treatment. A literature review identified a small number of aortitis cases all caused by prophylactic use of granulocyte colony-stimulating factors (G-CSFs), among which short-acting filgrastim was rarely encountered. The present and previous findings imply a possible relationship between aortitis and prophylactic G-CSF usage.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.0599-22