Monoamine metabolite concentrations in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia

Concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxy indoleacetic acid (5-HIAA) and homovanillic acid (HVA) were determined in lumbar cerebrospinal fluid (CSF) from control subjects and patients of both presenile and senile age with histologically verified Alzheimer's dementia. C...

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Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1984-05, Vol.47 (5), p.481-484
Main Authors: Palmer, A M, Sims, N R, Bowen, D M, Neary, D, Palo, J, Wikstrom, J, Davison, A N
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - pathology
Biological and medical sciences
Brain - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Female
Glycols - cerebrospinal fluid
Homovanillic Acid - cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid - cerebrospinal fluid
Lumbosacral Region
Male
Medical sciences
Methoxyhydroxyphenylglycol - cerebrospinal fluid
Middle Aged
Neurology
Phenylacetates - cerebrospinal fluid
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Summary:Concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxy indoleacetic acid (5-HIAA) and homovanillic acid (HVA) were determined in lumbar cerebrospinal fluid (CSF) from control subjects and patients of both presenile and senile age with histologically verified Alzheimer's dementia. CSF HVA increased with age in control but not in Alzheimer patients. HVA and 5-HIAA in the CSF of presenile Alzheimer patients was lower than that of age matched control subjects.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.47.5.481