Programmed death‑ligand 1 expression in tumor cells and tumor‑infiltrating lymphocytes are associated with depth of tumor invasion in penile cancer

The present study aimed to demonstrate the proportion of the programmed death-ligand 1 (PD-L1) expression in penile cancer patients and the association with clinicopathological parameters. Formalin-fixed paraffin-embedded specimens were obtained from 43 patients with primary penile squamous cell car...

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Bibliographic Details
Published in:Biomedical reports 2023-07, Vol.19 (1), p.44-44, Article 44
Main Authors: Sangkhamanon, Sakkarn, Kotano, Natcha, Sirithanaphol, Wichien, Rompsaithong, Ukrit, Kiatsopit, Pakorn, Sookprasert, Aumkhae, Wirasorn, Kosin, Twinprai, Prin, Watcharenwong, Piyakarn, Chindaprasirt, Jarin
Format: Article
Language:English
Subjects:
Antibodies
Apoptosis
Biomarkers
Blood platelets
Cancer
Cancer therapies
Care and treatment
Genital cancers
Immune system
Immunohistochemistry
Kidney cancer
Ligands
Lung cancer
Lymph nodes
Lymphatic system
Lymphocytes
Medical prognosis
Metastasis
Monoclonal antibodies
Neutrophils
Paraffin
Parameters
Patients
PD-L1 protein
Penis
Squamous cell carcinoma
Staining
Survival
Survival analysis
Tumor cells
Tumor-infiltrating lymphocytes
Tumors
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Summary:The present study aimed to demonstrate the proportion of the programmed death-ligand 1 (PD-L1) expression in penile cancer patients and the association with clinicopathological parameters. Formalin-fixed paraffin-embedded specimens were obtained from 43 patients with primary penile squamous cell carcinoma treated at Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, between 2008 and 2018. PD-L1 expression was evaluated by the immunohistochemistry using an SP263 monoclonal antibody. PD-L1 positivity was defined as >25% tumor cell staining or >25% tumor-associated immune cell staining. The correlation between PD-L1 expression and clinicopathological parameters was analyzed. A total of eight of 43 patients (18.6%) were identified as positive for PD-L1 expression in tumor cells and tumor-infiltrating lymphocytes. In the PD-L1 positive group, there was a significant association with pathological T stage (P=0.014) with a higher percentage of PD-L1 positive tumors in T1 stage compared with T2-T4 stage. In this cohort, there was a trend towards longer survival in patients with positive PD-L1 expression (5-year OS: 75% vs. 61.2%, P=0.19). Lymph node involvement and the location of tumor at the shaft of penis were two independent prognostic factors for survival. In conclusion, the PD-L1 expression was detected in 18% of penile cancer patients and high expression of PD-L1 was associated with the early T stage.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2023.1627