Epitranscriptomic turbo for autophagy boost: m6A reader YTHDF3

Mcroautophagy/autophagy plays an important role in maintaining homeostasis during nutrient starvation. However, whether epitranscriptomic events are involved in this process remains unclear. Our recent findings suggest that m 6 A reader YTHDF3 has an essential role in autophagy induction. Elevated m...

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Bibliographic Details
Published in:Autophagy 2023-06, Vol.19 (6), p.1882-1884
Main Authors: Hao, WeiChao, Dian, MeiJuan, Wang, JiaHong, Sun, Yan, Xiao, Dong
Format: Article
Language:English
Subjects:
Autophagic Punctum
Autophagy
epitranscriptomics
FOXO3
METTL3
nutrient starvation
YTHDF3
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Summary:Mcroautophagy/autophagy plays an important role in maintaining homeostasis during nutrient starvation. However, whether epitranscriptomic events are involved in this process remains unclear. Our recent findings suggest that m 6 A reader YTHDF3 has an essential role in autophagy induction. Elevated m 6 A modifications installed by METTL3 enable YTHDF3 to promote autophagosome formation and lysosomal function upon nutrient deficiency. This is due to YTHDF3 binding to the m 6 A modifications at the coding DNA sequence (CDS) and 3' untranslated region (UTR) around the stop codon of Foxo3 mRNA, recruiting EIF3A and EIF4B to facilitate FOXO3 translation, thus boosting autophagy. In this punctum, we discuss our finding for how YTHDF3 responds to nutrient starvation to promote autophagy flux, providing insights into RNA post-transcriptional modifications linking nutrient cues to autophagic upcycling.
ISSN:1554-8627
1554-8635
DOI:10.1080/15548627.2022.2146890