Patient-reported cognitive function among hematopoietic stem cell transplant and cellular therapy patients: a scoping review

Purpose Cognitive dysfunction is a known complication following cellular therapies (CT), which can be assessed through performance based and patient-reported measures. We performed a systematic scoping review to assess self-reported cognitive function measures used among adult CT patients and descri...

Full description

Saved in:
Bibliographic Details
Published in:Quality of life research 2023-04, Vol.32 (4), p.939-964
Main Authors: Cusatis, Rachel, Balza, Joanna, Uttke, Zachary, Kode, Vishwajit, Suelzer, Elizabeth, Shaw, Bronwen E., Flynn, Kathryn E.
Format: Article
Language:English
Subjects:
Adult
Antigens
Cancer therapies
Clinical outcomes
Cognition
Cognitive ability
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Medical schools
Medicine
Medicine & Public Health
Patients
Public Health
Quality of life
Quality of Life - psychology
Quality of Life Research
Review
Self Report
Sociology
Stem cell transplantation
Surveys and Questionnaires
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Cognitive dysfunction is a known complication following cellular therapies (CT), which can be assessed through performance based and patient-reported measures. We performed a systematic scoping review to assess self-reported cognitive function measures used among adult CT patients and describe long-term results, including associations with clinical outcomes. Methods Library databases were searched from inception to February 2020 according to PRISMA guidelines. Additional studies were identified through reference lists and trial protocols. Two members of the research team screened titles and abstracts and resolved discrepancies. Articles that met eligibility criteria continued to full-text review, with 25% double screening. Articles were removed if they (1) were not original research, peer-reviewed articles; (2) were the wrong disease, age, or treatment-specific patient population; (3) did not use patient-reported outcomes; (4) did not separately report cognitive function outcomes. Results Of the1952 articles, 56 were included. Twenty-one patient-reported measures of cognitive function were used; most frequently the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30), which includes a two-item cognitive function subscale (57%; n  = 32). Thirteen studies collected performance-based and self-reported measures and of those ( n  = 6) who assessed associations found moderate correlations (range r  = .13-.58). Longitudinal patterns showed declines in cognitive function soon after treatment (
ISSN:0962-9343
1573-2649
DOI:10.1007/s11136-022-03258-0