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Thyroid disease in cervical dystonia
There are many possible etiologies for cervical dystonia (CD), but a cause cannot be identified in most cases. Most recent attention has focused on genetic causes, although a few prior studies have highlighted autoimmune mechanisms instead. Because autoimmune disorders frequently co-exist, the curre...
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Published in: | Parkinsonism & related disorders 2023-02, Vol.107, p.105274-105274, Article 105274 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | There are many possible etiologies for cervical dystonia (CD), but a cause cannot be identified in most cases. Most recent attention has focused on genetic causes, although a few prior studies have highlighted autoimmune mechanisms instead. Because autoimmune disorders frequently co-exist, the current study evaluated the hypothesis that autoimmune disorders might be more common in CD than neurological controls.
The frequency of 32 common autoimmune disorders was evaluated using a systematic survey comparing 300 subjects with CD with 391 neurological controls.
The frequency of thyroid disease was significantly higher in CD (20%) compared with controls (6%). Regression analyses that accounted for age and sex revealed an odds ratio of 4.5 (95% CI 2.5–8.1, p < 0.001). All other autoimmune disorders occurred with similar frequencies in CD and controls.
Although these studies do not establish a mechanistic link between CD and autoimmune disease, they suggest the need for further attention to a potential relationship, and more specifically with thyroid disease.
•Cervical dystonia is a heterogenous disorder for which a cause cannot usually be found.•Anecdotal reports have suggested that some cases may be caused by autoimmune mechanisms.•Our study revealed that thyroid disease was more frequent in cervical dystonia compared with neurological controls.•These results suggest a relationship between cervical dystonia and autoimmune thyroid disease. |
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ISSN: | 1353-8020 1873-5126 |
DOI: | 10.1016/j.parkreldis.2022.105274 |