Review of natural compounds for potential psoriasis treatment

Psoriasis represents an immune-mediated disease with an unclear cause that’s marked by inflammation triggered by dysfunction in the immune system, which results in inflammation in various parts of the skin. There could be obvious symptoms, such as elevated plaques; these plaques may appear different...

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Bibliographic Details
Published in:Inflammopharmacology 2023-06, Vol.31 (3), p.1183-1198
Main Authors: Elkhawaga, Omali Y., Ellety, Mohamed M., Mofty, Sheref O., Ghanem, Mohamed S., Mohamed, Abdallah O.
Format: Article
Language:English
Subjects:
Adalimumab - therapeutic use
Allergology
Antibodies, Monoclonal - therapeutic use
Biomedical and Life Sciences
Biomedicine
Dermatology
Gastroenterology
Humans
Immunology
Inflammation - drug therapy
Interleukin-12
Middle Aged
Pharmacology/Toxicology
Psoriasis - drug therapy
Review
Rheumatology
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Summary:Psoriasis represents an immune-mediated disease with an unclear cause that’s marked by inflammation triggered by dysfunction in the immune system, which results in inflammation in various parts of the skin. There could be obvious symptoms, such as elevated plaques; these plaques may appear differently depending on the type of skin. This disease can cause inflammation in the elbows, lower back, scalp, knees, or other regions of the body. It can begin at any age, although it most commonly affects individuals between the ages of 50 and 60. Specific cells (such as T cells) have been observed to play an obvious role in the pathogenesis of psoriasis, in addition to specific immunological molecules such as TNF-, IL-12, IL-23, IL-17, and other molecules that can aid in the pathogenesis of psoriasis. So, during the past two decades, biologists have created chemical drugs that target these cells or molecules and therefore prevent the disease from occurring. Alefacept, efalizumab, Adalimumab, Ustekinumab, and Secukinumab are a few examples of chemical drugs. It was discovered that these chemical drugs have long-term side effects that can cause defects in the patient's body, such as the development of the rare but life-threatening disorder progressive multifocal leukoencephalopathy (PCL). Its rapidly progressive infection of the central nervous system caused by the JC virus and other drugs may cause increased production of neutralising anti-drug antibodies (ADA) and the risk of infusion reactions like pruritus, flushing, hypertension, headache, and rash. So, our context intends to talk in our review about natural products or plants that may have therapeutic characteristics for this disease and may have few or no side effects on the patient's body.
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-023-01178-0