Clinical significance of conduction velocity orientation vectors on cardiac mapping surfaces

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): This work was supported by the Lefoulon Delalande Foundation OBJECTIVE Electroanatomical maps using automated conduction velocity (CV) algorithms are now being calculated using 2D mapping tools. The basis...

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Published in:Europace (London, England) England), 2023-05, Vol.25 (Supplement_1)
Main Authors: Rodriguez Padilla, J, Anderson, R, Joens, C, Masse, S, Bhaskaran, A, Niri, A, Lai, P, Ali Azam, M, Lee, G, Vigmond, E, Nanthakumar, K
Format: Article
Language:English
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Summary:Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): This work was supported by the Lefoulon Delalande Foundation OBJECTIVE Electroanatomical maps using automated conduction velocity (CV) algorithms are now being calculated using 2D mapping tools. The basis of substrate-based functional assessment is to detect slow zones or slow CV of which isochronal late activation mapping (ILAM) is now commonly performed. We studied the accuracy of mapping surface 2D CV, compared to the 3D vectors, and the influence of mapping resolution in non-scarred animal and human heart models. Methods Two models were used: a healthy porcine Langendorff model with transmural needle electrodes and a computer stimulation model of the ventricles built from an MRI-segmented, excised human heart. Local activation times (LAT) within the 3D volume of the mesh were used to calculate true 3D CVs (direction and velocity) for different pixel resolutions ranging between 500 mm – 4 mm (3D CVs). CV was also calculated for endocardial surface-only LATs (2D CV). Results In the experimental model, surface (2D) CV was faster on the epicardium (0.509 m/s) compared to the endocardium (0.262 m/s, Figure 1). In stimulation models, 2D CV significantly exceeded 3D CVs across all mapping resolutions and increased as resolution decreased (Figure 2). 3D and 2D left ventricle CV at 500mm resolution increased from 429.2±189.3 mm/s to 527.7±253.8 mm/s (P
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/euad122.287