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Efficacy and safety outcomes of early versus late cryoballoon ablation of atrial fibrillation - 24-months-results from the Cryo Global Registry
Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Medtronic, Inc., Minneapolis, MN, USA Introduction Increasing evidence suggests early rhythm-control therapy in atrial fibrillation (AF) results in higher freedom from atrial arrhythmia (AA) recurrenc...
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Published in: | Europace (London, England) England), 2023-05, Vol.25 (Supplement_1) |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Abstract
Funding Acknowledgements
Type of funding sources: Private company. Main funding source(s): Medtronic, Inc., Minneapolis, MN, USA
Introduction
Increasing evidence suggests early rhythm-control therapy in atrial fibrillation (AF) results in higher freedom from atrial arrhythmia (AA) recurrence and improved cardiovascular outcomes. However, the impact of specifically early cryoballoon ablation (CBA) is not well known.
Purpose
To assess the impact of early CBA of atrial fibrillation on efficacy and safety outcomes.
Methods
We evaluated AA recurrence (≥30 sec after a 90-day blanking period), repeat ablation, and serious procedure-related complications in patients with early vs. later CBA (≤12 vs. >12 months from diagnosis) in patients enrolled in the prospective, multicenter (121 centers in 37 countries). Subjects underwent CBA and were followed either 12 or 24 months per local standard of care.
Results
A total of 3447 subjects were followed through 12 months and a subset of 1220 through 24 months. In summary, 1573 patients (46%) had early CBA treatment at a median [IQR] of 0.3 [0.1 – 0.6] years from AF diagnosis (age 62±12 years, 35.8% female, 71.4% paroxysmal AF), and 1874 (54%) had later treatment at a median of 3.4 [1.9 – 6.7] years after diagnosis (age 61±11 years, 36.2% female, 75.0% paroxysmal AF). Early treatment patients were less hypertensive (53.5% vs 57.9%, p=0.01), had smaller left atrial diameters (41±7mm vs 42±7mm, p |
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ISSN: | 1099-5129 1532-2092 |
DOI: | 10.1093/europace/euad122.682 |