Soluble CD137 and risk of hepatocellular carcinoma: nested case-control studies in cohorts in Shanghai and Singapore

The majority of hepatocellular carcinoma (HCC) cases occur in the presence of cirrhosis. Biomarkers of cirrhosis-associated immune dysfunction such as CD8+ T cell cytokines could aid HCC risk assessment. CD8+ T cell cytokines were determined in pre-diagnostic serum in two studies including 315 HCC c...

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Bibliographic Details
Published in:British journal of cancer 2023-06, Vol.128 (11), p.2081-2088
Main Authors: Thomas, Claire E, Adibi, Jennifer J, Kuipers, Allison L, Diergaarde, Brenda, Luu, Hung N, Jin, Aizhen, Koh, Woon-Puay, Gao, Yu-Tang, Adams-Haduch, Jennifer, Wang, Renwei, Lokshin, Anna, Behari, Jaideep, Yuan, Jian-Min
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular
CD137 antigen
CD8 antigen
China
Cirrhosis
Cohort Studies
Cytokines
Hepatitis B
Hepatocellular carcinoma
Humans
Inflammation
Liver cancer
Liver cirrhosis
Liver Neoplasms - epidemiology
Lymphocytes T
Macrophage inflammatory protein
Macrophage inflammatory protein 1
Perforin
Population studies
Risk assessment
Singapore
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:The majority of hepatocellular carcinoma (HCC) cases occur in the presence of cirrhosis. Biomarkers of cirrhosis-associated immune dysfunction such as CD8+ T cell cytokines could aid HCC risk assessment. CD8+ T cell cytokines were determined in pre-diagnostic serum in two studies including 315 HCC case-control pairs in the Shanghai Cohort Study (SCS) and 197 pairs in the Singapore Chinese Health Study (SCHS). Conditional logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) for HCC with levels of five cytokines-soluble CD137 (sCD137), soluble Fas (sFas), perforin, macrophage inflammatory protein 1-beta (MIP-1β), and tumour necrosis factor alpha (TNF-α). sCD137 levels were significantly higher in HCC cases than controls in both cohorts (Ps 
ISSN:0007-0920
1532-1827
DOI:10.1038/s41416-023-02223-z