Combined regression score predicts outcome after neoadjuvant treatment of oesophageal cancer

Histopathologic regression following neoadjuvant treatment (NT) of oesophageal cancer is a prognostic factor of survival, but the nodal status is not considered. Here, a score combining both to improve prediction of survival after neoadjuvant therapy is developed. Seven hundred and fifteen patients...

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Bibliographic Details
Published in:British journal of cancer 2023-06, Vol.128 (11), p.2025-2035
Main Authors: Damanakis, A I, Gebauer, F, Stapper, A, Schlößer, H A, Ghadimi, M, Schmidt, T, Schiffmann, L M, Fuchs, H, Zander, T, Quaas, A, Bruns, C J, Schroeder, W
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - pathology
Combined Modality Therapy
Esophageal cancer
Esophageal Neoplasms - pathology
Esophagectomy
Esophagus
Humans
Medical prognosis
Neoadjuvant Therapy
Neoplasm Staging
Prognosis
Retrospective Studies
Risk groups
Survival analysis
Treatment Outcome
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Summary:Histopathologic regression following neoadjuvant treatment (NT) of oesophageal cancer is a prognostic factor of survival, but the nodal status is not considered. Here, a score combining both to improve prediction of survival after neoadjuvant therapy is developed. Seven hundred and fifteen patients with oesophageal squamous cell (SCC) or adenocarcinoma (AC) undergoing NT and esophagectomy were analysed. Histopathologic response was classified according to percentage of vital residual tumour cells (VRTC): complete response (CR) without VRTC, major response with 10% VRTC. Nodal stage was classified as ypN0 and ypN+. Kaplan-Meier and Cox regression were used for survival analysis. Survival analysis identified three groups with significantly different mortality risks: (1) low-risk group for CR (ypT0N0) with 72% 5-year overall survival (5y-OS), (2) intermediate-risk group for minor/major responders and ypN0 with 59% 5y-OS, and (3) high-risk group for minor/major responders and ypN+ with 20% 5y-OS (p 
ISSN:0007-0920
1532-1827
DOI:10.1038/s41416-023-02232-y