Croquemort elicits activation of the immune deficiency pathway in ticks

The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain e...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2023-05, Vol.120 (20), p.e2208673120-e2208673120
Main Authors: O'Neal, Anya J, Singh, Nisha, Rolandelli, Agustin, Laukaitis, Hanna J, Wang, Xiaowei, Shaw, Dana K, Young, Brianna D, Narasimhan, Sukanya, Dutta, Shraboni, Snyder, Greg A, Samaddar, Sourabh, Marnin, Liron, Butler, L Rainer, Mendes, M Tays, Cabrera Paz, Francy E, Valencia, Luisa M, Sundberg, Eric J, Fikrig, Erol, Pal, Utpal, Weber, David J, Pedra, Joao H F
Format: Article
Language:English
Subjects:
Animals
Arthropoda
Arthropods
Bacterial diseases
Bacterial Infections
Biological Sciences
Borrelia burgdorferi - genetics
CD36 antigen
Crustaceans
Immune response
Insects
Ixodes - microbiology
Kinases
Lipids
Localization
Lyme disease
Lyme Disease - microbiology
Microorganisms
Molting
NF-kappa B
Peptidoglycan recognition proteins
Proteins
Spirochetes
Ticks
Vector-borne diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain elusive. Here, we show that an homolog of croquemort (Crq), a CD36-like protein, promotes activation of the tick IMD pathway. Crq exhibits plasma membrane localization and binds the lipid agonist 1-palmitoyl-2-oleoyl- -glycero-3-phosphoglycerol. Crq regulates the IMD and jun N-terminal kinase signaling cascades and limits the acquisition of the Lyme disease spirochete . Additionally, nymphs silenced for display impaired feeding and delayed molting to adulthood due to a deficiency in ecdysteroid synthesis. Collectively, we establish a distinct mechanism for arthropod immunity outside of insects and crustaceans.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2208673120