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Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants
•Confirmatory factor analysis indicates that the five-factor dysphoric arousal model best fits the Posttraumatic Stress Disorder Checklist data in the Million Veteran Program.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress diso...
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| Published in: | Psychiatry research 2023-01, Vol.319, p.114994-114994, Article 114994 |
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| container_end_page | 114994 |
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| container_start_page | 114994 |
| container_title | Psychiatry research |
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| creator | Overstreet, Cassie Levey, Daniel F. Zhou, Hang Harrington, Kelly M. Quaden, Rachel Stein, Murray B. Gelernter, Joel Pietrzak, Robert H. |
| description | •Confirmatory factor analysis indicates that the five-factor dysphoric arousal model best fits the Posttraumatic Stress Disorder Checklist data in the Million Veteran Program.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress disorder is noninvariant across genetically identified ancestry and sex (European, African, Ad mixed, and East Asian ancestry.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress disorder is also noninvariant across genetically sex (male and female).
The Million Veteran Program (MVP) uses the posttraumatic stress disorder symptoms (PTSD) Checklist 17 (PCL-17) self-report to assess PTSD. Existing literature suggests that the five-factor dysphoric arousal model best represents the PTSD symptom clusters; this can be tested within MVP, one of the largest samples collected with suitable data. We compared factor models within MVP across genetically defined subsamples (ancestry [European, African, admixed American, and East Asian], sex) via multi-group confirmatory factor analyses in a sample of 279,897 participants. The five-factor dysphoric arousal model best fit the PCL-17 data, consistent with previous findings. The factor structure could also be imposed across all groups tested. Verifying the factor structure provides a framework for future phenotypic and genotypic analyses within MVP and other samples. |
| doi_str_mv | 10.1016/j.psychres.2022.114994 |
| format | article |
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The Million Veteran Program (MVP) uses the posttraumatic stress disorder symptoms (PTSD) Checklist 17 (PCL-17) self-report to assess PTSD. Existing literature suggests that the five-factor dysphoric arousal model best represents the PTSD symptom clusters; this can be tested within MVP, one of the largest samples collected with suitable data. We compared factor models within MVP across genetically defined subsamples (ancestry [European, African, admixed American, and East Asian], sex) via multi-group confirmatory factor analyses in a sample of 279,897 participants. The five-factor dysphoric arousal model best fit the PCL-17 data, consistent with previous findings. The factor structure could also be imposed across all groups tested. Verifying the factor structure provides a framework for future phenotypic and genotypic analyses within MVP and other samples.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2022.114994</identifier><identifier>PMID: 36516638</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Checklist ; Diagnostic and Statistical Manual of Mental Disorders ; Factor Analysis, Statistical ; Five factor dysphoric arousal model ; Humans ; Multi-group confirmatory factor analysis ; Posttraumatic stress disorder ; Self Report ; Stress Disorders, Post-Traumatic - diagnosis ; Veterans</subject><ispartof>Psychiatry research, 2023-01, Vol.319, p.114994-114994, Article 114994</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-6a4177ba6ac9cba03bc36f0e9666bc2cd13a8b15afe548d5215945942305ccc03</citedby><cites>FETCH-LOGICAL-c505t-6a4177ba6ac9cba03bc36f0e9666bc2cd13a8b15afe548d5215945942305ccc03</cites><orcidid>0000-0001-9668-183X ; 0000-0001-9564-2871 ; 0000-0003-2342-153X ; 0000-0002-7694-6391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36516638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Overstreet, Cassie</creatorcontrib><creatorcontrib>Levey, Daniel F.</creatorcontrib><creatorcontrib>Zhou, Hang</creatorcontrib><creatorcontrib>Harrington, Kelly M.</creatorcontrib><creatorcontrib>Quaden, Rachel</creatorcontrib><creatorcontrib>Stein, Murray B.</creatorcontrib><creatorcontrib>Gelernter, Joel</creatorcontrib><creatorcontrib>Pietrzak, Robert H.</creatorcontrib><creatorcontrib>Million Veteran Program</creatorcontrib><title>Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>•Confirmatory factor analysis indicates that the five-factor dysphoric arousal model best fits the Posttraumatic Stress Disorder Checklist data in the Million Veteran Program.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress disorder is noninvariant across genetically identified ancestry and sex (European, African, Ad mixed, and East Asian ancestry.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress disorder is also noninvariant across genetically sex (male and female).
The Million Veteran Program (MVP) uses the posttraumatic stress disorder symptoms (PTSD) Checklist 17 (PCL-17) self-report to assess PTSD. Existing literature suggests that the five-factor dysphoric arousal model best represents the PTSD symptom clusters; this can be tested within MVP, one of the largest samples collected with suitable data. We compared factor models within MVP across genetically defined subsamples (ancestry [European, African, admixed American, and East Asian], sex) via multi-group confirmatory factor analyses in a sample of 279,897 participants. The five-factor dysphoric arousal model best fit the PCL-17 data, consistent with previous findings. The factor structure could also be imposed across all groups tested. Verifying the factor structure provides a framework for future phenotypic and genotypic analyses within MVP and other samples.</description><subject>Checklist</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Factor Analysis, Statistical</subject><subject>Five factor dysphoric arousal model</subject><subject>Humans</subject><subject>Multi-group confirmatory factor analysis</subject><subject>Posttraumatic stress disorder</subject><subject>Self Report</subject><subject>Stress Disorders, Post-Traumatic - diagnosis</subject><subject>Veterans</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkUFv1DAQhS0EokvhL1Q-FqlZbCe2kxOgFQWkldoDnC1nMul6SeJgOyv67-vVthWckEaaw3zznj2PkAvO1pxx9WG_nuM97ALGtWBCrDmvmqZ6QVa81qLQXJQvySqDsuC65mfkTYx7xpjgTfOanJVKcqXKekX-XFtIPtCYwgJpCUh9T9MO6exjSsEuo00OjmOMkXYu-tBhoLBD-DW4mOjl7WabPd5TN1Ghm6u60XR0w-D8RA-YMNiJzsHfBTvS2YYs5mY7pfiWvOrtEPHdYz8nP6-__Nh8K7Y3X79vPm8LkEymQtmKa91aZaGB1rKyhVL1DBulVAsCOl7auuXS9iirupOCy6bKJUomAYCV5-TjSXde2hE7wCn_ajBzcKMN98ZbZ_6dTG5n7vzB5DPXla51Vrh8VAj-94IxmdFFwGGwE_olGqGzs8o4z6g6oRB8jAH7Zx_OjoLK7M1TbuaYmznllhcv_n7l89pTUBn4dAIw3-rgMJgIDifAzgWEZDrv_ufxAByNryA</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Overstreet, Cassie</creator><creator>Levey, Daniel F.</creator><creator>Zhou, Hang</creator><creator>Harrington, Kelly M.</creator><creator>Quaden, Rachel</creator><creator>Stein, Murray B.</creator><creator>Gelernter, Joel</creator><creator>Pietrzak, Robert H.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9668-183X</orcidid><orcidid>https://orcid.org/0000-0001-9564-2871</orcidid><orcidid>https://orcid.org/0000-0003-2342-153X</orcidid><orcidid>https://orcid.org/0000-0002-7694-6391</orcidid></search><sort><creationdate>20230101</creationdate><title>Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants</title><author>Overstreet, Cassie ; Levey, Daniel F. ; Zhou, Hang ; Harrington, Kelly M. ; Quaden, Rachel ; Stein, Murray B. ; Gelernter, Joel ; Pietrzak, Robert H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-6a4177ba6ac9cba03bc36f0e9666bc2cd13a8b15afe548d5215945942305ccc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Checklist</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Factor Analysis, Statistical</topic><topic>Five factor dysphoric arousal model</topic><topic>Humans</topic><topic>Multi-group confirmatory factor analysis</topic><topic>Posttraumatic stress disorder</topic><topic>Self Report</topic><topic>Stress Disorders, Post-Traumatic - diagnosis</topic><topic>Veterans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Overstreet, Cassie</creatorcontrib><creatorcontrib>Levey, Daniel F.</creatorcontrib><creatorcontrib>Zhou, Hang</creatorcontrib><creatorcontrib>Harrington, Kelly M.</creatorcontrib><creatorcontrib>Quaden, Rachel</creatorcontrib><creatorcontrib>Stein, Murray B.</creatorcontrib><creatorcontrib>Gelernter, Joel</creatorcontrib><creatorcontrib>Pietrzak, Robert H.</creatorcontrib><creatorcontrib>Million Veteran Program</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Overstreet, Cassie</au><au>Levey, Daniel F.</au><au>Zhou, Hang</au><au>Harrington, Kelly M.</au><au>Quaden, Rachel</au><au>Stein, Murray B.</au><au>Gelernter, Joel</au><au>Pietrzak, Robert H.</au><aucorp>Million Veteran Program</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>319</volume><spage>114994</spage><epage>114994</epage><pages>114994-114994</pages><artnum>114994</artnum><issn>0165-1781</issn><eissn>1872-7123</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>•Confirmatory factor analysis indicates that the five-factor dysphoric arousal model best fits the Posttraumatic Stress Disorder Checklist data in the Million Veteran Program.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress disorder is noninvariant across genetically identified ancestry and sex (European, African, Ad mixed, and East Asian ancestry.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress disorder is also noninvariant across genetically sex (male and female).
The Million Veteran Program (MVP) uses the posttraumatic stress disorder symptoms (PTSD) Checklist 17 (PCL-17) self-report to assess PTSD. Existing literature suggests that the five-factor dysphoric arousal model best represents the PTSD symptom clusters; this can be tested within MVP, one of the largest samples collected with suitable data. We compared factor models within MVP across genetically defined subsamples (ancestry [European, African, admixed American, and East Asian], sex) via multi-group confirmatory factor analyses in a sample of 279,897 participants. The five-factor dysphoric arousal model best fit the PCL-17 data, consistent with previous findings. The factor structure could also be imposed across all groups tested. Verifying the factor structure provides a framework for future phenotypic and genotypic analyses within MVP and other samples.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>36516638</pmid><doi>10.1016/j.psychres.2022.114994</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9668-183X</orcidid><orcidid>https://orcid.org/0000-0001-9564-2871</orcidid><orcidid>https://orcid.org/0000-0003-2342-153X</orcidid><orcidid>https://orcid.org/0000-0002-7694-6391</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Checklist Diagnostic and Statistical Manual of Mental Disorders Factor Analysis, Statistical Five factor dysphoric arousal model Humans Multi-group confirmatory factor analysis Posttraumatic stress disorder Self Report Stress Disorders, Post-Traumatic - diagnosis Veterans |
| title | Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants |
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