Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants

•Confirmatory factor analysis indicates that the five-factor dysphoric arousal model best fits the Posttraumatic Stress Disorder Checklist data in the Million Veteran Program.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress diso...

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Bibliographic Details
Published in:Psychiatry research 2023-01, Vol.319, p.114994-114994, Article 114994
Main Authors: Overstreet, Cassie, Levey, Daniel F., Zhou, Hang, Harrington, Kelly M., Quaden, Rachel, Stein, Murray B., Gelernter, Joel, Pietrzak, Robert H.
Format: Article
Language:English
Subjects:
Checklist
Diagnostic and Statistical Manual of Mental Disorders
Factor Analysis, Statistical
Five factor dysphoric arousal model
Humans
Multi-group confirmatory factor analysis
Posttraumatic stress disorder
Self Report
Stress Disorders, Post-Traumatic - diagnosis
Veterans
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Summary:•Confirmatory factor analysis indicates that the five-factor dysphoric arousal model best fits the Posttraumatic Stress Disorder Checklist data in the Million Veteran Program.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress disorder is noninvariant across genetically identified ancestry and sex (European, African, Ad mixed, and East Asian ancestry.•Multi-group confirmatory factor analyses indicates that the five-factor dysphoric arousal model of posttraumatic stress disorder is also noninvariant across genetically sex (male and female). The Million Veteran Program (MVP) uses the posttraumatic stress disorder symptoms (PTSD) Checklist 17 (PCL-17) self-report to assess PTSD. Existing literature suggests that the five-factor dysphoric arousal model best represents the PTSD symptom clusters; this can be tested within MVP, one of the largest samples collected with suitable data. We compared factor models within MVP across genetically defined subsamples (ancestry [European, African, admixed American, and East Asian], sex) via multi-group confirmatory factor analyses in a sample of 279,897 participants. The five-factor dysphoric arousal model best fit the PCL-17 data, consistent with previous findings. The factor structure could also be imposed across all groups tested. Verifying the factor structure provides a framework for future phenotypic and genotypic analyses within MVP and other samples.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2022.114994