HIV replication and latency in monocytes and macrophages

The relevance of monocyte and macrophage reservoirs in virally suppressed people with HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a moderate life span and lack self-renewing potential. However, recent studies have challenged this dogma and now suggest an important rol...

Full description

Saved in:
Bibliographic Details
Published in:Seminars in immunology 2021-01, Vol.51, p.101472-101472, Article 101472
Main Authors: Veenhuis, Rebecca T., Abreu, Celina M., Shirk, Erin N., Gama, Lucio, Clements, Janice E.
Format: Article
Language:English
Subjects:
Animals
CD4-Positive T-Lymphocytes
HIV
HIV Infections
Humans
Latency
Macrophages
Monocytes
Replication
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
SIV
Virus Replication
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The relevance of monocyte and macrophage reservoirs in virally suppressed people with HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a moderate life span and lack self-renewing potential. However, recent studies have challenged this dogma and now suggest an important role of these cell as long-lived HIV reservoirs. Lentiviruses have a long-documented association with macrophages and abundant evidence exists that macrophages are important target cells for HIV in vivo. A critical understanding of HIV infection, replication, and latency in macrophages is needed in order to determine the appropriate method of measuring and eliminating this cellular reservoir. This review provides a brief discussion of the biology and acute and chronic infection of monocytes and macrophages, with a more substantial focus on replication, latency and measurement of the reservoir in cells of myeloid origin.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2021.101472