Parental age, genetic mutation, and cerebral palsy

Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations...

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Bibliographic Details
Published in:Journal of medical genetics 1993-01, Vol.30 (1), p.44-46
Main Authors: Fletcher, N A, Foley, J
Format: Article
Language:English
Subjects:
Adolescent
Adult
age
Athetosis
Biological and medical sciences
Birth Order
cerebral palsy
Cerebral Palsy - classification
Cerebral Palsy - genetics
Cerebral Palsy - pathology
Dystonia
Genes, Dominant
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hemiplegia
Humans
Infant, Newborn
man
Maternal Age
Medical sciences
Middle Aged
Mutation
Nervous system (semeiology, syndromes)
Neurology
Paralysis
Paternal Age
Quadriplegia
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Summary:Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.
ISSN:0022-2593
1468-6244
1468-6244
DOI:10.1136/jmg.30.1.44