Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae : Contributions of type II topoisomerase mutations and efflux to levels of resistance

We report on amino acid substitutions in the quinolone resistance-determining region of type II topisomerases and the prevalence of reserpine-inhibited efflux for 70 clinical isolates of S. pneumoniae for which the ciprofloxacin MIC is >/=4 microgram/ml and 28 isolates for which the ciprofloxacin...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2000-11, Vol.44 (11), p.3049-3054
Main Authors: BAST, Darrin J, LOW, Donald E, DUNCAN, Carla L, KILBURN, Laurie, MANDELL, Lionel A, DAVIDSON, Ross J, DE AZAVEDO, Joyce C. S
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Biological and medical sciences
Biological Transport, Active
Ciprofloxacin - pharmacology
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II - genetics
DNA Topoisomerases, Type II - physiology
DNA-Binding Proteins - genetics
DNA-Binding Proteins - physiology
Drug Resistance, Microbial - genetics
GyrA protein
Humans
Mechanisms of Resistance
Medical sciences
Microbial Sensitivity Tests
ParC protein
Pharmacology. Drug treatments
Phenotype
Streptococcus pneumoniae
Streptococcus pneumoniae - drug effects
Streptococcus pneumoniae - enzymology
Streptococcus pneumoniae - genetics
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Summary:We report on amino acid substitutions in the quinolone resistance-determining region of type II topisomerases and the prevalence of reserpine-inhibited efflux for 70 clinical isolates of S. pneumoniae for which the ciprofloxacin MIC is >/=4 microgram/ml and 28 isolates for which the ciprofloxacin MIC is
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.44.11.3049-3054.2000