Prevalence and Predictors of Peripheral Vascular Disease Amongst Predialysis Hypertensive Chronic Kidney Disease Patients in Southern Nigeria

Peripheral vascular disease (PVD) is an atherosclerotic disease associated with increased morbidity and mortality among chronic kidney disease (CKD) patients. However, despite the substantial burden of PVD in CKD, local data are lacking. To determine the prevalence and predictors of PVD in predialys...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-03, Vol.15 (3), p.e36752-e36752
Main Authors: Ovwasa, Henry, Aiwuyo, Henry O, Okoye Ca, Ogochukwu, Umuerri, Ejiroghene M, Obasohan, Austine, Unuigbe, Evelyn, Rajora, Nilum
Format: Article
Language:English
Subjects:
Age
Ankle
Atherosclerosis
Automation
Blood pressure
Calcification
Cardiac/Thoracic/Vascular Surgery
Cardiology
Creatinine
Diabetes
Diabetic retinopathy
Fasting
Hematuria
Hypertension
Intermittent claudication
Kidney diseases
Males
Morbidity
Mortality
Nephrology
Population
Teaching hospitals
Ultrasonic imaging
Veins & arteries
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Summary:Peripheral vascular disease (PVD) is an atherosclerotic disease associated with increased morbidity and mortality among chronic kidney disease (CKD) patients. However, despite the substantial burden of PVD in CKD, local data are lacking. To determine the prevalence and predictors of PVD in predialysis CKD patients. The study was cross-sectional. One hundred fifty hypertensive CKD patients and age- and sex-matched hypertensive non-CKD subjects were consecutively enrolled at the renal unit of Delta State University Teaching Hospital (DELSUTH), Oghara. Structured questionnaires were used to obtain information on participants' demographic data and health status. PVD was defined by an ankle-brachial index of < 0.9 or > 1.4 in either lower extremity. eGFR was calculated from serum creatinine using the MDRD equation. The mean ages of the study and control groups were 48±14 and 51±15years, respectively. The sex ratio was 3:2 in favour of males for both the study and control groups. The majority of the study group was in CKD stage 4 (44%). The prevalence of PVD was higher among the CKD group compared with controls (24.0% vs. 14.7%). Of the CKD patients with PVD, 11.1% were symptomatic. Predictors of PVD in the study group were eGFR (B=0.010, 95%CI: 0.007-0.013), diastolic BP (B=-0.005, 95%CI: -0.007- -0.002), MAP (B=-0.018, 95%CI: -0.027- -0.008), urinary ACR (B=-0.0036, 95%CI: -0.040- -0.024) and smoking history (p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.36752