Serum Fluorescent Advanced Glycation End (F-AGE) products in gestational diabetes patients

ABSTRACT Objectives Advanced glycation end products (AGEs) are involved in the pathogenesis and complications of diabetes mellitus (DM). Gestational DM (GDM) is characterized by increased glycemia and oxidative stress, which are factors associated with high serum AGE concentrations. The aim of this...

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Published in:Archives of Endocrinology and Metabolism 2017-05, Vol.61 (3), p.233-237
Main Authors: Lobo Júnior, João Paulo, Brescansin, Catiane Pompilio, Santos-Weiss, Izabella C. R., Welter, Marciane, Souza, Emanuel Maltempi de, Rego, Fabiane Gomes de Moraes, Picheth, Geraldo, Alberton, Dayane
Format: Article
Language:English
Subjects:
Diabetes screening
fluorescent advanced glycation end products
gestational diabetes
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Summary:ABSTRACT Objectives Advanced glycation end products (AGEs) are involved in the pathogenesis and complications of diabetes mellitus (DM). Gestational DM (GDM) is characterized by increased glycemia and oxidative stress, which are factors associated with high serum AGE concentrations. The aim of this study was to evaluate the utility of a serum fluorescence AGE (F-AGE) method as a screening tool for gestational diabetes. Subjects and methods Serum samples from 225 GDM patients and 217 healthy pregnant women (healthy controls) were diluted 50-fold in phosphate-buffered saline, and the AGEs were estimated by fluorometric analysis (λEx 350 nm/ λEm 440 nm). Results No significant (P > 0.05) differences in AGE concentrations, expressed in Arbitrary Units (UA/mL × 104), were observed in the women with GDM or in the healthy controls. Furthermore, F-AGE concentrations did not change significantly during the pregnancy (12-32 weeks of gestation). Only the GDM group had a positive correlation (r = 0.421; P < 0.001) between F-AGEs and serum creatinine concentrations. Conclusion It was not possible to distinguish women with gestational diabetes from the healthy controls on the basis of serum F-AGE concentrations.
ISSN:2359-3997
2359-4292
2359-3997
2359-4292
DOI:10.1590/2359-3997000000238