Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial

ABSTRACT Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training. Subjects and methods: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile ran...

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Published in:Archives of Endocrinology and Metabolism 2018-10, Vol.62 (5), p.530-536
Main Authors: Werneck, Francisco Zacaron, Coelho, Emerson Filipino, Almas, Saulo Peters, Garcia, Marília Mendes do Nascimento, Bonfante, Heloina Lamha Machado, Lima, Jorge Roberto Perrout de, Vigário, Patrícia dos Santos, Mainenti, Míriam Raquel Meira, Teixeira, Patrícia de Fátima dos Santos, Vaisman, Mário
Format: Article
Language:English
Subjects:
exercise training
functional capacity
Hypothyroidism
Original
quality of life
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Summary:ABSTRACT Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training. Subjects and methods: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL. In the second phase, a randomized clinical trial was conducted where only women with sHT were randomly divided into two groups: sHT-Tr (n = 10) - participants that performed an exercise program - and sHT-Sed (n = 10) - controls. Exercise training consisted of 60 minutes of aerobic activities (bike and treadmill), three times a week, for 16 weeks. The HRQoL was assessed by the SF-36 questionnaire in the early and at the end of four months. Results: Women with sHT had lower scores on functional capacity domain in relation to the euthyroid ones (770 ± 23.0 vs. 88.8 ± 14.6; p = 0.020). The sHT-Tr group improved functional capacity, general health, emotional aspects, mental and physical component of HRQoL after training period, while the sHT-Sed group showed no significant changes. Conclusion: After 16 weeks of aerobic exercise training, there were remarkable improvements in HRQoL in women with sHT.
ISSN:2359-3997
2359-4292
2359-4292
DOI:10.20945/2359-3997000000073