Longitudinal study of clinical and neurophysiological features in essential tremor

Background and purpose Essential tremor (ET) is a common and heterogeneous disorder characterized by postural/kinetic tremor of the upper limbs and other body segments and by non‐motor symptoms, including cognitive and psychiatric abnormalities. Only a limited number of longitudinal studies have com...

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Bibliographic Details
Published in:European journal of neurology 2023-03, Vol.30 (3), p.631-640
Main Authors: Angelini, Luca, Paparella, Giulia, De Biase, Alessandro, Maraone, Annalisa, Panfili, Matteo, Berardelli, Isabella, Cannavacciuolo, Antonio, Di Vita, Antonella, Margiotta, Roberta, Fabbrini, Giovanni, Berardelli, Alfredo, Bologna, Matteo
Format: Article
Language:English
Subjects:
Abnormalities
Cognitive ability
Disorders
essential tremor
Essential Tremor - diagnosis
Evaluation
Female
Genetics
Humans
Investigations
kinematic
Kinematics
Longitudinal Studies
Mental Disorders
Motor task performance
Movement Disorders
neurophysiology
Original
Segments
Signs and symptoms
Tremor
Tremor (Muscular contraction)
Tremor - diagnosis
tremor classification
Tremors
Upper Extremity
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Summary:Background and purpose Essential tremor (ET) is a common and heterogeneous disorder characterized by postural/kinetic tremor of the upper limbs and other body segments and by non‐motor symptoms, including cognitive and psychiatric abnormalities. Only a limited number of longitudinal studies have comprehensively and simultaneously investigated motor and non‐motor symptom progression in ET. Possible soft signs that configure the ET‐plus diagnosis are also under‐investigated in follow‐up studies. We aimed to longitudinally investigate the progression of ET manifestations by means of clinical and neurophysiological evaluation. Methods Thirty‐seven ET patients underwent evaluation at baseline (T0) and at follow‐up (T1; mean interval ± SD = 39.89 ± 9.83 months). The assessment included the clinical and kinematic evaluation of tremor and voluntary movement execution, as well as the investigation of cognitive and psychiatric disorders. Results A higher percentage of patients showed tremor in multiple body segments and rest tremor at T1 as compared to T0 (all p‐values 
ISSN:1351-5101
1468-1331
DOI:10.1111/ene.15650