Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction

Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize t...

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Published in:Journal of Zhejiang University. B. Science 2023-04, Vol.24 (4), p.281-300
Main Authors: Li, Jingru, Ma, Haocheng, Wu, Xinyu, Sun, Guihu, Yang, Ping, Peng, Yunzhu, Wang, Qixian, Wang, Luqiao
Format: Article
Language:eng ; chi
Subjects:
Apoptosis
Bioinformatics
Biomarkers
Biomedical and Life Sciences
Biomedicine
Computational Biology
Gene expression
Gene set enrichment analysis
Humans
MicroRNAs - genetics
Myocardial infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - genetics
Non-coding RNA
Regulatory mechanisms (biology)
Review
Reviews
RNA
RNA, Untranslated - genetics
Signal transduction
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Summary:Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and “pre-necrotic” biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B2200459