The Potential Role of Etanercept in the Management of Post-stroke Pain: A Literature Review

Strokes are the second leading cause of death and disability worldwide. The brain injury resulting from stroke produces a persistent neuroinflammatory response in the brain, resulting in a spectrum of neurologic dysfunction affecting stroke survivors chronically, also known as post-stroke pain. Exce...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-03, Vol.15 (3), p.e36185-e36185
Main Authors: Joseph, Andrew M, Karas, Monica, Jara Silva, Cesar E, Leyva, Melissa, Salam, Abdus, Sinha, Mehul, Asfaw, Yonathan Aliye, Fonseca, Ayesha, Cordova, Steven, Reyes, Marlon, Quinonez, Jonathan, Ruxmohan, Samir
Format: Article
Language:English
Subjects:
Ataxia
Chronic pain
Hemorrhage
Hypoxia
Inflammation
Literature reviews
Mortality
Neurology
Pain Management
Patients
Psoriasis
Rheumatoid arthritis
Spasticity
Stroke
Therapeutics
Thrombosis
Traumatic brain injury
Tumor necrosis factor-TNF
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Summary:Strokes are the second leading cause of death and disability worldwide. The brain injury resulting from stroke produces a persistent neuroinflammatory response in the brain, resulting in a spectrum of neurologic dysfunction affecting stroke survivors chronically, also known as post-stroke pain. Excess production of tumor necrosis factor alpha (TNF alpha) in the cerebrospinal fluid (CSF) of stroke survivors has been implicated in post-stroke pain. Therefore, this literature review aims to assess and review the role of perispinal etanercept in the management of post-stroke pain. Several studies have shown statistically significant evidence that etanercept, a TNF alpha inhibitor, can reduce symptoms present in post-stroke syndrome by targeting the excess TNF alpha produced in the CSF. Studies have also shown improvements in not only post-stroke pain but also in traumatic brain injury and dementia. Further research is needed to explore the effects of TNF alpha on stroke prognosis and determine the optimal frequency and duration of etanercept treatment for post-stroke pain.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.36185