Synaptic Loss in Frontotemporal Dementia Revealed by [11C]UCB‐J Positron Emission Tomography

Objective Synaptic loss is an early feature of neurodegenerative disease models, and is severe in post mortem clinical studies, including frontotemporal dementia. Positron emission tomography (PET) with radiotracers that bind to synaptic vesicle glycoprotein 2A enables quantification of synaptic den...

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Bibliographic Details
Published in:Annals of neurology 2023-01, Vol.93 (1), p.142-154
Main Authors: Malpetti, Maura, Jones, P. Simon, Cope, Thomas E., Holland, Negin, Naessens, Michelle, Rouse, Matthew A., Rittman, Timothy, Savulich, George, Whiteside, David J., Street, Duncan, Fryer, Tim D., Hong, Young T., Milicevic Sephton, Selena, Aigbirhio, Franklin I., O′Brien, John T., Rowe, James B.
Format: Article
Language:English
Subjects:
Atrophy
Binding
Brain - metabolism
Cognitive ability
Cortex (insular)
Dementia
Dementia disorders
Density
Emission analysis
Frontal Lobe
Frontotemporal dementia
Frontotemporal Dementia - diagnostic imaging
Frontotemporal Dementia - metabolism
Glycoproteins
Humans
In vivo methods and tests
Magnetic resonance imaging
Neurodegeneration
Neurodegenerative Diseases
Neuroimaging
Pick Disease of the Brain
Positron emission
Positron emission tomography
Positron-Emission Tomography - methods
Radioactive tracers
Substantia grisea
Synapses
Synaptic density
Temporal cortex
Temporal lobe
Tomography
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Summary:Objective Synaptic loss is an early feature of neurodegenerative disease models, and is severe in post mortem clinical studies, including frontotemporal dementia. Positron emission tomography (PET) with radiotracers that bind to synaptic vesicle glycoprotein 2A enables quantification of synaptic density in vivo. This study used [11C]UCB‐J PET in participants with behavioral variant frontotemporal dementia (bvFTD), testing the hypothesis that synaptic loss is severe and related to clinical severity. Methods Eleven participants with clinically probable bvFTD and 25 age‐ and sex‐matched healthy controls were included. Participants underwent dynamic [11C]UCB‐J PET, structural magnetic resonance imaging, and a neuropsychological battery, including the revised Addenbrooke Cognitive Examination, and INECO frontal screening. General linear models compared [11C]UCB‐J binding potential maps and gray matter volume between groups, and assessed associations between synaptic density and clinical severity in patients. Analyses were also performed using partial volume corrected [11C]UCB‐J binding potential from regions of interest (ROIs). Results Patients with bvFTD showed severe synaptic loss compared to controls. [11C]UCB‐J binding was reduced bilaterally in medial and dorsolateral frontal regions, inferior frontal gyri, anterior and posterior cingulate gyrus, insular cortex, and medial temporal lobe. Synaptic loss in the frontal and cingulate regions correlated significantly with cognitive impairments. Synaptic loss was more severe than atrophy. Results from ROI‐based analyses mirrored the voxelwise results. Interpretation In accordance with preclinical models, and human postmortem evidence, there is widespread frontotemporal loss of synapses in symptomatic bvFTD, in proportion to severity. [11C]UCB‐J PET could support translational studies and experimental medicine strategies for new disease‐modifying treatments for neurodegeneration. ANN NEUROL 2023;93:142–154
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.26543