Sex difference in patients with controlled acromegaly—A multicentre survey

Objective Active acromegaly is subject to sex differences in growth hormone (GH) and Insulin like growth factor 1 (IGF‐I) patterns as well as clinical features but whether this also pertains to controlled disease is unclear. Design In a cross‐sectional, multi‐centre study, 84 patients with acromegal...

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Published in:Clinical endocrinology (Oxford) 2023-01, Vol.98 (1), p.74-81
Main Authors: Dal, Jakob, Rosendal, Christian, Karmisholt, Jesper, Feldt‐Rasmussen, Ulla, Andersen, Marianne S., Klose, Marianne, feltoft, Claus, Heck, Ansgar, Nielsen, Eigil H., Jørgensen, Jens O. L.
Format: Article
Language:eng ; nor
Subjects:
Acromegaly
age
Cross-Sectional Studies
Disease control
Fasting
Female
Females
FFA
Gender differences
Glucose tolerance
Growth hormone
Humans
IGF‐I
Insulin
Insulin-Like Growth Factor I
Laboratory testing
Male
Original
ORIGINAL ARTICLES
Patients
pituitary adenoma
Post-menopause
Quality of Life
Questionnaires
sex
Sex Characteristics
Sex differences
Somatostatin
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Summary:Objective Active acromegaly is subject to sex differences in growth hormone (GH) and Insulin like growth factor 1 (IGF‐I) patterns as well as clinical features but whether this also pertains to controlled disease is unclear. Design In a cross‐sectional, multi‐centre study, 84 patients with acromegaly (F = 43, M = 41), who were considered controlled after surgery alone (n = 23) or during continued somatostatin receptor ligand (SRL) treatment (n = 61), were examined. Methods Serum concentrations of GH, insulin, glucose and free fatty acid (FFA) were measured during an oral glucose tolerance test (OGTT) together with baseline serum IGF‐I and completion of two HR‐Qol questionnaires (acromegaly quality of life questionnaire [AcroQol] and Patient‐assessed Acromegaly Symptom Questionnaire [PASQ]). Results The mean age at the time of the study was 57 (±1.1) years and the majority of females (were postmenopausal. Females had significantly higher fasting GH but comparable IGF‐I standard deviation scores (SDS). Using fasting GH 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14750