Recognition of facial emotion expressions and perceptual processes in 22q11.2 deletion syndrome

Background Social cognition (SC) deficits and of its facial emotion expression (FEE) component have been described in 22q11.2 Deletion Syndrome (22q11.2DS), a high‐risk for schizophrenia (SCZ) systemic genetic syndrome. Correlations between deficits in FEE skills and visual‐spatial abilities in peop...

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Published in:Early intervention in psychiatry 2023-01, Vol.17 (1), p.76-84
Main Authors: Buzzanca, Antonino, Accinni, Tommaso, Frascarelli, Marianna, Troisi, Eloisa, Kotzalidis, Georgios D., Di Bonaventura, Carlo, Fanella, Martina, Putotto, Carolina, Marino, Bruno, Pasquini, Massimo, Biondi, Massimo, Di Fabio, Fabio
Format: Article
Language:English
Subjects:
22q11.2 deletion syndrome
Cognition
Correlation analysis
Deletion
DiGeorge Syndrome - psychology
Emotions
facial emotional expression
Genetic disorders
Health risks
Humans
Multivariate analysis
Original
positive and negative syndrome scale
Psychosis
Psychotic Disorders
Recognition
Recognition, Psychology
Schizophrenia
Schizophrenia - genetics
social cognition
social inference
Social skills
Variance analysis
visual‐spatial abilities
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Summary:Background Social cognition (SC) deficits and of its facial emotion expression (FEE) component have been described in 22q11.2 Deletion Syndrome (22q11.2DS), a high‐risk for schizophrenia (SCZ) systemic genetic syndrome. Correlations between deficits in FEE skills and visual‐spatial abilities in people with 22q11.2DS warrant investigation. Methods The sample consisted of 37 patients with 22q11.2DS (DEL), 19 with 22q11.2DS and psychosis (DEL‐SCZ), 23 with idiopathic SCZ, and 48 healthy controls. We assessed FEE through The Ekman 60 Faces test (EK‐F60), visual‐spatial skills with Raven's Standard Progressive Matrices, and symptom severity with the positive And negative syndrome scale. Statistics were conducted through multivariate analysis of variance and correlation analysis. Results Patients with 22q11.2DS performed worse that the other groups in recognizing Surprise, Disgust, Rage, Fear, and Neutral expressions on the EK‐F60. Recognition of Surprise and Disgust correlated positively with visual‐spatial abilities in patients with 22q11.2DS; negative and cognitive symptoms correlated negatively with recognition of Sadness, Surprise, and Disgust. Conclusions Patients with 22q11.2DS show impairments of both peripheral and central steps of the emotional recognition process, leading to SC deficits. The latter are present regardless of the presence of a full‐blown psychosis.
ISSN:1751-7885
1751-7893
DOI:10.1111/eip.13295