Mutational analysis of DNMT3A improves the prognostic stratification of patients with acute myeloid leukemia

Nucleophosmin1 (NPM1) mutations are the most frequently detected gene mutations in acute myeloid leukemia (AML) and are considered a favorable prognostic factor. We retrospectively analyzed the prognosis of 605 Japanese patients with de novo AML, including 174 patients with NPM1‐mutated AML. Althoug...

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Bibliographic Details
Published in:Cancer science 2023-04, Vol.114 (4), p.1297-1308
Main Authors: Wakita, Satoshi, Marumo, Atsushi, Morita, Kaoru, Kako, Shinichi, Toya, Takashi, Najima, Yuho, Doki, Noriko, Kanda, Junya, Kuroda, Junya, Mori, Shinichiro, Satake, Atsushi, Usuki, Kensuke, Ueki, Toshimitsu, Uoshima, Nobuhiko, Kobayashi, Yutaka, Kawata, Eri, Nakayama, Kazutaka, Nagao, Yuhei, Shono, Katsuhiro, Shibusawa, Motoharu, Tadokoro, Jiro, Hagihara, Masao, Uchiyama, Hitoji, Uchida, Naoyuki, Kubota, Yasushi, Kimura, Shinya, Nagoshi, Hisao, Ichinohe, Tatsuo, Kurosawa, Saiko, Motomura, Sayuri, Hashimoto, Akiko, Muto, Hideharu, Sato, Eriko, Ogata, Masao, Mitsuhashi, Kenjiro, Ando, Jun, Tashiro, Haruko, Sakaguchi, Masahiro, Yui, Shunsuke, Arai, Kunihito, Kitano, Tomoaki, Miyata, Miho, Arai, Haruka, Kanda, Masayuki, Itabashi, Kako, Fukuda, Takahiro, Kanda, Yoshinobu, Yamaguchi, Hiroki
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Classification
DNA (Cytosine-5-)-Methyltransferases - genetics
DNA methyltransferase
DNA Mutational Analysis
DNMT3A
Flt3 protein
Genotypes
Humans
Induction therapy
Leukemia, Myeloid, Acute - genetics
Medical prognosis
Multivariate analysis
Mutation
NPM1
Nucleophosmin - genetics
Original
ORIGINAL ARTICLES
Patients
Point mutation
Prognosis
prognostic factor
Protein-tyrosine kinase
Remission
Retrospective Studies
Risk groups
triple mutation
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Description
Summary:Nucleophosmin1 (NPM1) mutations are the most frequently detected gene mutations in acute myeloid leukemia (AML) and are considered a favorable prognostic factor. We retrospectively analyzed the prognosis of 605 Japanese patients with de novo AML, including 174 patients with NPM1‐mutated AML. Although patients with NPM1‐mutated AML showed a high remission rate, this was not a favorable prognostic factor for overall survival (OS); this is contrary to generally accepted guidelines. Comprehensive gene mutation analysis showed that mutations in codon R882 of DNA methyltransferase 3A (DNMT3AR882 mutations) were a strong predicative factor indicating poor prognosis in all AML (p 
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.15720