Management of Locally Advanced Laryngeal Cancer-From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe

Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to December 2022) with 152 patients diagnosed with laryn...

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Published in:International journal of environmental research and public health 2023-03, Vol.20 (6), p.4737
Main Authors: Cîrstea, Anca-Ionela, Berteșteanu, Șerban Vifor Gabriel, Scăunașu, Răzvan-Valentin, Popescu, Bogdan, Bejenaru, Paula Luiza, Simion-Antonie, Catrinel Beatrice, Berteșteanu, Gloria Simona, Diaconu, Teodora Elena, Taher, Petra Bianca, Rujan, Simona-Andreea, Oașă, Irina-Doinița, Grigore, Raluca
Format: Article
Language:English
Subjects:
Ablation (Surgery)
Adult
Aged
Aged, 80 and over
Alcohol
Cancer
Cancer therapies
Carbon dioxide
Carbon dioxide lasers
Chemotherapy
Digestive tract
Disease
Dysphagia
Dyspnea
Electronic cigarettes
Female
Health risks
Hospitals
Humans
Laryngeal cancer
Laryngeal carcinoma
Laryngeal Neoplasms - epidemiology
Laryngeal Neoplasms - surgery
Laryngectomy - methods
Larynx
Laser ablation
Male
Medical imaging
Medical prognosis
Medical research
Medicine, Experimental
Middle Aged
Patients
Prevention
Radiation therapy
Reconstructive surgery
Respiration
Retrospective Studies
Risk Factors
Smoking
Surgery
Tertiary Care Centers
Tobacco
Treatment Outcome
Tumors
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Summary:Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to December 2022) with 152 patients diagnosed with laryngeal cancer from a tertiary hospital in Romania. The average age of the patients was 62 years old for both sexes, with a range from 44 to 83 years. The most frequent symptom was dysphonia with or without dyspnea in 142 cases (93.42%), followed by dyspnea alone in nine patients (5.92%) and dysphagia in one case (0.66%). Surgical treatment in this study consisted of partial laryngectomy (CO laser transoral tumor ablation, supraglottic horizontal laryngectomy or hemilaryngectomy), or total laryngectomy. The main treatment was total laryngectomy (63%). For the eight patients with initial organ preservation treatment, the average time of recurrence was about two-and-a-half years. For the four patients who underwent a total circular pharyngo-laryngectomy, the upper digestive tract needed to be rebuilt with a salivary bypass tube or with a tubed myocutaneous flap from the major pectoralis muscle. One strong point is characteristic of the study group in gathering patients with advanced stages of laryngeal carcinoma candidates for salvage surgery and extended reconstruction methods. The development of new prevention protocols is mandatory in Eastern European countries.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph20064737