A Conserved Role for Stomatin Domain Genes in Olfactory Behavior

The highly-conserved stomatin domain has been identified in genes throughout all classes of life. In animals, different stomatin domain-encoding genes have been implicated in the function of the kidney, red blood cells, and specific neuron types, although the underlying mechanisms remain unresolved....

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Bibliographic Details
Published in:eNeuro 2023-03, Vol.10 (3), p.ENEURO.0457-22.2023
Main Authors: Liang, Xiaoyu, Taylor, Morgan, Napier-Jameson, Rebekah, Calovich-Benne, Canyon, Norris, Adam
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
Cell Membrane - metabolism
Membrane Proteins - metabolism
Mice
Mice, Knockout
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
New Research
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Summary:The highly-conserved stomatin domain has been identified in genes throughout all classes of life. In animals, different stomatin domain-encoding genes have been implicated in the function of the kidney, red blood cells, and specific neuron types, although the underlying mechanisms remain unresolved. In one well-studied example of stomatin domain gene function, the gene and its mouse homolog are required for the function of mechanosensory neurons, where they modulate the activity of mechanosensory ion channels on the plasma membrane. Here, we identify an additional shared function for and in a very different sensory context, that of olfaction. In worms, we find that a subset of stomatin domain genes are expressed in olfactory neurons, but only is strongly required for olfactory behavior. acts cell-autonomously and multiple alternatively-spliced isoforms of can be substituted for each other. We generate a knock-out (KO) mouse and demonstrate that, like its worm homolog , it is required for olfactory behavior. In mice, is not required for odor detection, but is required for odor discrimination. Therefore, in addition to their shared roles in mechanosensory behavior, and also have a shared role in olfactory behavior.
ISSN:2373-2822
2373-2822
DOI:10.1523/ENEURO.0457-22.2023