Indian National Association for Study of the Liver (INASL) Guidance Paper on Nomenclature, Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease globally and in India. The already high burden of NAFLD in India is expected to further increase in the future in parallel with the ongoing epidemics of obesity and type 2 diabetes mellitus. Given the high prevalence...

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Published in:Journal of clinical and experimental hepatology 2023-03, Vol.13 (2), p.273-302
Main Authors: Duseja, Ajay, Singh, S.P., De, Arka, Madan, Kaushal, Rao, Padaki Nagaraja, Shukla, Akash, Choudhuri, Gourdas, Saigal, Sanjiv, Shalimar, Arora, Anil, Anand, Anil C., Das, Ashim, Kumar, Ashish, Eapen, Chundamannil E., Devadas, Krishnadas, Shenoy, Kotacherry T., Panigrahi, Manas, Wadhawan, Manav, Rathi, Manish, Kumar, Manoj, Choudhary, Narendra S., Saraf, Neeraj, Nath, Preetam, Kar, Sanjib, Alam, Seema, Shah, Samir, Nijhawan, Sandeep, Acharya, Subrat K., Aggarwal, Vinayak, Saraswat, Vivek A., Chawla, Yogesh K.
Format: Article
Language:English
Subjects:
Clinical Practice Guidelines
fatty liver
hepatic steatosis
MAFLD
NASH
nonalcoholic steatohepatitis
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Summary:Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease globally and in India. The already high burden of NAFLD in India is expected to further increase in the future in parallel with the ongoing epidemics of obesity and type 2 diabetes mellitus. Given the high prevalence of NAFLD in the community, it is crucial to identify those at risk of progressive liver disease to streamline referral and guide proper management. Existing guidelines on NAFLD by various international societies fail to capture the entire landscape of NAFLD in India and are often difficult to incorporate in clinical practice due to fundamental differences in sociocultural aspects and health infrastructure available in India. A lot of progress has been made in the field of NAFLD in the 7 years since the initial position paper by the Indian National Association for the Study of Liver on NAFLD in 2015. Further, the ongoing debate on the nomenclature of NAFLD is creating undue confusion among clinical practitioners. The ensuing comprehensive review provides consensus-based, guidance statements on the nomenclature, diagnosis, and treatment of NAFLD that are practically implementable in the Indian setting.
ISSN:0973-6883
2213-3453
DOI:10.1016/j.jceh.2022.11.014