Serologic responses to COVID-19 vaccination in children with history of multisystem inflammatory syndrome (MIS-C)

Understanding the serological responses to COVID-19 vaccination in children with history of MIS-C could inform vaccination recommendations. We prospectively enrolled seven children hospitalized with MIS-C and measured SARS-CoV-2 binding IgG antibodies to spike protein variants longitudinally pre- an...

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Bibliographic Details
Published in:Vaccine 2023-04, Vol.41 (17), p.2743-2748
Main Authors: Perez, Maria A., Hsiao, Hui-Mien, Chen, Xuemin, Kunkel, Amber, Baida, Nadine, Hussaini, Laila, Lu, Austin T., Kao, Carol M., Laham, Federico R., Hunstad, David A., Beltran, Yajira, Hammett, Teresa A., Godfred-Cato, Shana, Chahroudi, Ann, Anderson, Evan J., Belay, Ermias, Rostad, Christina A.
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Neutralizing
Antibodies, Viral
Antibody-dependent cell-mediated cytotoxicity
Binding
BNT162 Vaccine
Child
Children
Coronaviruses
COVID-19
COVID-19 - prevention & control
COVID-19 Testing
COVID-19 Vaccines
Cytotoxicity
Enrollments
Hospitalization
Humans
Immunoglobulin G
Inflammation
Intensive care
Multisystem inflammatory syndrome in children
Neutralizing
Pediatrics
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Short Communication
Spike protein
Toxicity
Vaccination
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Summary:Understanding the serological responses to COVID-19 vaccination in children with history of MIS-C could inform vaccination recommendations. We prospectively enrolled seven children hospitalized with MIS-C and measured SARS-CoV-2 binding IgG antibodies to spike protein variants longitudinally pre- and post-Pfizer-BioNTech BNT162b2 primary series COVID-19 vaccination. We found that SARS-CoV-2 variant cross-reactive IgG antibodies variably waned following acute MIS-C, but were significantly boosted with vaccination and maintained for up to 3 months. We then compared post-vaccination binding, pseudovirus neutralizing, and functional antibody-dependent cell-mediated cytotoxicity (ADCC) titers to the reference strain (Wuhan-hu-1) and Omicron variant (B.1.1.529) among previously healthy children (n = 16) and children with history of MIS-C (n = 7) or COVID-19 (n = 8). Despite the breadth of binding antibodies elicited by vaccination in all three groups, pseudovirus neutralizing and ADCC titers were significantly reduced to the Omicron variant.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2023.03.021