Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3'-azido-3'-deoxythymidine

The effect of zidovudine (3'-azido-3'-deoxythymidine; AZT) was investigated in four breast cancer cell lines, a T4 cell leukemia, and a normal breast cell line in vitro. AZT inhibited the growth of all tumoral cell lines, but it did so in a wide range of concentrations. The growth of a nor...

Full description

Saved in:
Bibliographic Details
Published in:Clinical cancer research 1998-03, Vol.4 (3), p.693
Main Authors: Melana, S M, Holland, J F, Pogo, B G
Format: Article
Language:English
Subjects:
Antimetabolites, Antineoplastic - pharmacology
Breast - cytology
Breast - drug effects
Breast Neoplasms - enzymology
Breast Neoplasms - pathology
Cell Division - drug effects
Cell Line
Cell Survival - drug effects
Clone Cells
Female
Humans
Telomerase - antagonists & inhibitors
Tumor Cells, Cultured
Zidovudine - pharmacology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of zidovudine (3'-azido-3'-deoxythymidine; AZT) was investigated in four breast cancer cell lines, a T4 cell leukemia, and a normal breast cell line in vitro. AZT inhibited the growth of all tumoral cell lines, but it did so in a wide range of concentrations. The growth of a normal breast cell line was also inhibited, although it required a much higher concentration. Furthermore, AZT inhibited colony formation in soft agar and telomerase activity. These results indicated that AZT can be potentially used, alone or in combination, as an anti-breast cancer agent.
ISSN:1078-0432
1557-3265